Tag Archives: T-cells
The allergies go marching on: the atopic march and the temporal relationship of allergic diseases
Atopic/allergic family of diseases affects >20% of the global population and encompasses allergic asthma, hay fever, food allergy, atopic dermatitis, and allergic rhinitis. Frequently, individuals with an allergic condition develop another allergic disease. The atopic march theory
T-cell subsets in HIV infection
The human immunodeficiency virus (HIV) is a virus that assaults the body’s immunologic system. If HIV is not tackled, it can eventually drive the organism to AIDS, which a dreadful condition known as acquired immunodeficiency syndrome. In
Antigen-expressing regulatory T cells can protect against allergic reactions
Our immune systems are designed to protect us from dangerous foreign invaders, like viruses, bacteria or parasites. However, sometimes we respond to usually harmless foreign materials, e.g. pollens or food, the results of which can be mild
Stable housing can significantly improve health outcomes in women living with HIV
Unstable housing, including homelessness, is a key socioeconomic determinant of poor health outcomes and premature death in the United States. Housing-insecure individuals are more likely to delay seeking medical care due to costs, lack of health insurance,
The doors of the cell’s nucleus play a critical role in the survival and function of immune cells
Our immune system has a fascinating ability to distinguish between what does or does not belong to our body. This ability allows it to fight off infectious agents without harming our own cells. T cells are key
Inhibitors of intracellular enzymes for treatment of multiple sclerosis
Lymphocytes are white blood cells that are central in the immune response to foreign microorganisms. Like all cells, lymphocytes have a membrane, a lipid bilayer, that envelops the content of the cell. Proteins attached to the cell
Novel anti-inflammatory adjuvants for vaccines to prevent and/or treat autoimmune diseases
The increase during the last 30 years in the incidence of autoimmune diseases (AD) in the developed countries, points to environmental rather than genetic risk factors. Indeed, studies have shown that ADs are rare in countries where
Increased blood immune regulation in autoimmunity?
Through centuries, the immune system evolved to become highly proficient in protecting the human body from invading threats. Part of its strength relies on antibodies produced within germinal centres (GC). These structures form intricate networks of immune
Go with the flow: Studying the movement of T-cells to sites of inflammation
Inflammation is the protective response of the immune system that aids the removal of invading infectious agents and repair tissue injury. It involves the movement of white blood cells (leukocytes) from the bloodstream, through the cells lining
The T cell IFT20 interactome: new insights into immune synapse assembly regulation by the IFT system
T lymphocytes are key cellular components of the immune system that are essential for the elimination of viral, bacterial and parasitic infections as well as of malignant cells. T cell activation is initiated following recognition of pathogen-
Activation: a double-edged sword for Treg
Regulatory T cells (Tregs) are a specialized subset of T cells. As the name suggests, they play a role in controlling and regulating other immune cells. Tregs, characterized by the expression of the forkhead/winged-helix transcription factor Foxp3,
Anti-CD20 treatment shows changes not only in B-lymphocytes but also in T-subpopulations
In renal pathology, Rituximab has been proven to be useful in the treatment of some primary glomerulopathies, vasculitis with renal involvement, severe lupus with kidney disease, and especially in renal transplantation, where it is applied during the
Epstein Barr Virus (EBV) infection empowers B lymphocytes for autoimmunity
The human body is under constant threat of foreign invaders (bacteria, viruses, parasites) that can cause infectious diseases. The reason why this often does not occur is the immune system, a complex collection of molecules and cells
Gut microbiota: A potential trigger of rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder characterized by synovitis in multiple joints and systemic comorbidities. Both genetic and environmental agents are thought to be the risk factors for arthritis. Recent studies have suggested that
The oncolytic virus ∆PK has multi-modal anti-tumor activity
Oncolytic viruses (OVs) are an emerging cancer therapeutic based on tumor cell lysis by replicating virus and the resulting release of cellular proteins [viz. tumor-associated antigens (TAAs)], which modulate tumor immunogenic cell death (ICD). OVs have a
Lymphocytes T and Treg as prognostic factors of newly diagnosed DLBCL patients
Diffuse large B-cell lymphoma (DLBCL) is an aggressive and most common form of non-Hodgkin lymphoma. The mechanism of DLBCL pathogenesis is not fully understood. Malignant B-cells responsible for lymphoma formation are believed to arise from different stages
Microfluidic tumor models help pre-clinical screening of T cell cancer immunotherapies
Cancer immunotherapy draws upon the patient’s own immune system to recognize and fight the disease. One form of cancer immunotherapy is known as adoptive T cell therapy (ACT) consisting of isolation, genetic manipulation and reinfusion into the
Zinc – A beneficial player in autoimmune diseases
Essential trace elements, especially zinc, are indispensable for a proper immune function. Zinc deficiency or excess causes severe impairment of the immune response. So far, an increased susceptibility to infections, increased number of transplant rejections, development of
Is our immune system mistaking tumours for foetuses?
Tumours are abnormal growths of tissue where cells produced by the body get out of control and divide at a rapid and unregulated pace. And – when you think about it – embryos too are masses of
Polyfunctional T cells induced potent anti-tumor efficacy
Adoptive T cell therapy is a form of cancer immunotherapy using T cells to target cancer cells. In adoptive T cell therapy, white blood cells are collected from cancer patients, T cells (CD4+ and CD8+ cells) within
