Tag Archives: therapy
Perspectives for anti-tuberculosis therapy with additional drug activities to counteract drug resistance
Generally, antibiotic therapies use single antibiotics to combat sensitive bacteria. The standard of antituberculosis therapy includes four antibacterial agents that all have different modes of activities in the initial phase of a tuberculosis infection with mycobacterium tuberculosis.
A molecular passport authorizes intracellular travel for a potential cancer therapy antibody
Whether from external environmental factors or spontaneous intracellular processes, the DNA in our cells is under constant bombardment by DNA damage. Because unrepaired DNA damage can cause cell death, our cells have evolved vital mechanisms to repair
Why photobiomodulation therapy is helpful for diabetic wound healing? Fibroblast answers!
It is an obvious well-known issue that diabetic wounds are poorly healing, but the molecular and cellular alterations leading to this impairment is not clear. Many studies concluded the dysfunction of dermal fibroblasts as the main responsible
Health care utilization for chronic musculoskeletal pain risk: Lessons from the CRASH study
Each year, over four million people go to U.S. Emergency Departments (ED) after a motor vehicle crash (MVC). Although the vast majority of patients are sent home without any serious injuries, many will experience aches and pains
Heart medication and metabolism: What physicians should reflect on to keep them in harmony
Cardiovascular diseases are the leading cause of death globally and have been for a long time. This spotlight has ensured that doctors treating patients with heart problems have a wide variety of medications to work with. Most
International Conference on Stem Cell & Gene Therapy. Rome, Italy. September 16-18, 2020
Pleasure and honour in extending you a warmly invitation to all the participants on behalf of “Magnus corpus” from all over the world to attend International Conference on Stem Cell & Gene Therapy during September 16th-18th, 2020 at Rome,
Heat, diet and lifestyles control longevity in animals and man
The inactivation of the heat shock gene called Sirtuin 1 (Sirt 1) is associated with many chronic diseases such as diabetes, non alcoholic fatty liver disease (NAFLD), cardiovascular disease and neurodegenerative diseases. Factors such as body temperature
Molecular targeted therapy in alveolar soft part sarcoma
Alveolar soft part sarcoma is a malignant and rare tumor that includes about 1% of all STS (soft tissue sarcoma), and usually occurs in adolescents and young adults. This type of cancer has tendency toward distant metastasis
Targeting microRNAs for thyroid cancer therapy
The thyroid gland is a small butterfly-shaped endocrine organ located at the base of the throat, just below the Adam´s apple. Its function is to concentrate dietary iodine from the bloodstream and produce thyroid hormones, which have
Phage therapy: a one-hundred-year-old alternative to modern, chemical antibiotics
Phage therapy is the use of bacterial viruses, known as bacteriophages, or phages, to control or eliminate problematic bacteria (Fig. 1). Targeted bacteria can range from biofouling agents to agricultural pests to human pathogens, etc. As has
Making mountains out of molehills: how stem cells become platelets
You have 100,000 km of plumbing (blood vessels) in your body. What then keeps them from leaking? This essential work is carried out by tiny cells called platelets, which are able to form a plug to stop
Polarized light therapy: Illuminating immunity
What is it?: Light has been used as an alternative mode for the treatment of diseases, since the ancient Egyptians basked in the sun to restore their energy. Phototherapies are modern treatments in which light is used
Acute ischemic stroke: Can clinical risk factors exclude more women than men from thrombolysis therapy
Acute ischemic stroke is the physiologic manifestation of lack of perfusion to the brain. This lack of blood flow may be secondary to thrombosis of a large vessel, an embolus from elsewhere that lodges into a smaller
Ultrapure cells for liver research
Worldwide, hepatic fibrosis, cirrhosis and hepatocellular carcinoma cause considerable human suffering and high economic burdens. Causally responsible for the accumulation of excess scar tissue within the diseased liver are hepatic stellate cells (HSCs) representing 5-8% of the
Acting in mechanisms of aging to delay/prevent Alzheimer’s disease
Alzheimer’s disease (AD), a severely debilitating and ultimately fatal brain disorder, affects millions worldwide. To date, clinical efforts to find a cure or adequate treatment have met with dispiriting failure. The disease is now on an ominous
RKIP and YY1: The ‘good’ and the ‘bad’ shields in the protection of cancer spreading and resistance to therapies
Cancer originates from all of the uncorrected mutations occurring in the DNA of the cell that lead to abnormal cell growth. Accordingly, the accumulation of these mutations transforms a normal cell into an “immortal” cancer cell with
Antithrombotic therapy duration after coronary stenting: finding the sweet-spot with a novel clinical risk score
Coronary atherosclerosis is still the principal cause of morbidity and mortality in western countries, by inducing ischemia or infarction of the myocardium. Percutaneous treatment of atherosclerotic lesions is nowadays the most common form of treatment of such
New therapy for the treatment of childhood bone cancer
Cancer in children and young adults is rare, with survival rates being very high, mainly depending on the treatment. The biggest proportion of this diagnosis will be on leukaemia and brain tumours, with just about 3% of
Applying nanopharmacology to obstetrics: A novel targeted drug delivery system for the uterus
Pregnancy is a dangerous period for both the mother and foetus. Being born too early (preterm birth) is the leading cause of death and disease in children <5 years of age, while insufficient uterine contractions during or
Discovery of Bag3-P209L signaling mechanism brings hope for therapeutic options currently in development
Myofibrillar myopathy (MFM) is a group of rare genetic disorders that cause both skeletal and cardiac muscle weakness. Mutations in the Bcl2-associated Athanogene 3 (Bag3) protein, highly expressed in striated muscle, are reported to cause a particularly
