Tag Archives: therapy

Perspectives for anti-tuberculosis therapy with additional drug activities to counteract drug resistance

AoS. Perspectives for Antituberculosis Therapy with Additional Drug Activities to Counteract Drug Resistance

Generally, antibiotic therapies use single antibiotics to combat sensitive bacteria. The standard of antituberculosis therapy includes four antibacterial agents that all have different modes of activities in the initial phase of a tuberculosis infection with mycobacterium tuberculosis.

A molecular passport authorizes intracellular travel for a potential cancer therapy antibody

AoS. A Molecular Passport Authorizes Intracellular Travel for a Potential Cancer.

Whether from external environmental factors or spontaneous intracellular processes, the DNA in our cells is under constant bombardment by DNA damage. Because unrepaired DNA damage can cause cell death, our cells have evolved vital mechanisms to repair

Why photobiomodulation therapy is helpful for diabetic wound healing? Fibroblast answers!

AoS. diabetic wound healing

It is an obvious well-known issue that diabetic wounds are poorly healing, but the molecular and cellular alterations leading to this impairment is not clear. Many studies concluded the dysfunction of dermal fibroblasts as the main responsible

Health care utilization for chronic musculoskeletal pain risk: Lessons from the CRASH study

Each year, over four million people go to U.S. Emergency Departments (ED) after a motor vehicle crash (MVC). Although the vast majority of patients are sent home without any serious injuries, many will experience aches and pains

Heart medication and metabolism: What physicians should reflect on to keep them in harmony

Cardiovascular diseases are the leading cause of death globally and have been for a long time. This spotlight has ensured that doctors treating patients with heart problems have a wide variety of medications to work with. Most

International Conference on Stem Cell & Gene Therapy. Rome, Italy. September 16-18, 2020

International Conference on Stem Cell & Gene Therapy 2020. AoS

Pleasure and honour in extending you a warmly invitation to all the participants on behalf of “Magnus corpus” from all over the world to attend International Conference on  Stem Cell & Gene Therapy during September 16th-18th, 2020 at Rome,

Heat, diet and lifestyles control longevity in animals and man

Heat, Diet and Lifestyles control Longevity in Animals and Man

The inactivation of the heat shock gene called Sirtuin 1 (Sirt 1) is associated with many chronic diseases such as diabetes, non alcoholic fatty liver disease (NAFLD), cardiovascular disease and neurodegenerative diseases. Factors such as body temperature

Molecular targeted therapy in alveolar soft part sarcoma

Molecular Targeted Therapy in Alveolar Soft Part Sarcoma

Alveolar soft part sarcoma is a malignant and rare tumor that includes about 1% of all STS (soft tissue sarcoma), and usually occurs in adolescents and young adults. This type of cancer has tendency toward distant metastasis

Targeting microRNAs for thyroid cancer therapy

Schematic model explaining the oncogenic actions of miR-146b and the consequences of its inhibition in thyroid cancer

The thyroid gland is a small butterfly-shaped endocrine organ located at the base of the throat, just below the Adam´s apple. Its function is to concentrate dietary iodine from the bloodstream and produce thyroid hormones, which have

Phage therapy: a one-hundred-year-old alternative to modern, chemical antibiotics

Google Scholar searches on the query

Phage therapy is the use of bacterial viruses, known as bacteriophages, or phages, to control or eliminate problematic bacteria (Fig. 1). Targeted bacteria can range from biofouling agents to agricultural pests to human pathogens, etc. As has

Making mountains out of molehills: how stem cells become platelets

Heamatopoietic stem cells purified from cord blood or bone

You have 100,000 km of plumbing (blood vessels) in your body. What then keeps them from leaking? This essential work is carried out by tiny cells called platelets, which are able to form a plug to stop

Polarized light therapy: Illuminating immunity

What is it?: Light has been used as an alternative mode for the treatment of diseases, since the ancient Egyptians basked in the sun to restore their energy. Phototherapies are modern treatments in which light is used

Acute ischemic stroke: Can clinical risk factors exclude more women than men from thrombolysis therapy

Acute ischemic stroke is the physiologic manifestation of lack of perfusion to the brain. This lack of blood flow may be secondary to thrombosis of a large vessel, an embolus from elsewhere that lodges into a smaller

Ultrapure cells for liver research

Worldwide, hepatic fibrosis, cirrhosis and hepatocellular carcinoma cause considerable human suffering and high economic burdens. Causally responsible for the accumulation of excess scar tissue within the diseased liver are hepatic stellate cells (HSCs) representing 5-8% of the

Acting in mechanisms of aging to delay/prevent Alzheimer’s disease

Alzheimer’s disease (AD), a severely debilitating and ultimately fatal brain disorder, affects millions worldwide. To date, clinical efforts to find a cure or adequate treatment have met with dispiriting failure. The disease is now on an ominous

RKIP and YY1: The ‘good’ and the ‘bad’ shields in the protection of cancer spreading and resistance to therapies

Cancer originates from all of the uncorrected mutations occurring in the DNA of the cell that lead to abnormal cell growth. Accordingly, the accumulation of these mutations transforms a normal cell into an “immortal” cancer cell with

Antithrombotic therapy duration after coronary stenting: finding the sweet-spot with a novel clinical risk score

Coronary atherosclerosis is still the principal cause of morbidity and mortality in western countries, by inducing ischemia or infarction of the myocardium. Percutaneous treatment of atherosclerotic lesions is nowadays the most common form of treatment of such

New therapy for the treatment of childhood bone cancer

Cancer in children and young adults is rare, with survival rates being very high, mainly depending on the treatment. The biggest proportion of this diagnosis will be on leukaemia and brain tumours, with just about 3% of

Applying nanopharmacology to obstetrics: A novel targeted drug delivery system for the uterus

Pregnancy is a dangerous period for both the mother and foetus. Being born too early (preterm birth) is the leading cause of death and disease in children <5 years of age, while insufficient uterine contractions during or

Discovery of Bag3-P209L signaling mechanism brings hope for therapeutic options currently in development

Myofibrillar myopathy (MFM) is a group of rare genetic disorders that cause both skeletal and cardiac muscle weakness. Mutations in the Bcl2-associated Athanogene 3 (Bag3) protein, highly expressed in striated muscle, are reported to cause a particularly