Tag Archives: tuberculosis

Perspectives for anti-tuberculosis therapy with additional drug activities to counteract drug resistance

AoS. Perspectives for Antituberculosis Therapy with Additional Drug Activities to Counteract Drug Resistance

Generally, antibiotic therapies use single antibiotics to combat sensitive bacteria. The standard of antituberculosis therapy includes four antibacterial agents that all have different modes of activities in the initial phase of a tuberculosis infection with mycobacterium tuberculosis.

Driving time delays treatment initiation for tuberculosis in Uganda

Driving time delays treatment initiation for tuberculosis. Atlas of Science

We investigated the association between distance to health care facilities and delay in treatment initiation for patients with tuberculosis in Kampala, Uganda. We used a theoretical construct known as appraisal delay, which is the approximate time in

Cost-effectiveness of rapid diagnosis of drug-resistant tuberculosis

Globally, tuberculosis (TB) is a leading cause of premature death. There are treatments for tuberculosis, but drug-resistant strains of tuberculosis have emerged, mostly due to improper or incomplete treatment.  If diagnosed properly in a timely manner, extremely

Anti-tubercular peptides: Future puissant weapon for tuberculosis therapy

Tuberculosis (TB) is one of the oldest and deadliest airborne asymptomatic tropical diseases in the world, caused by M. tuberculosis (Mtb), infecting one third of the global populace. At present, the emergence of multidrug-resistant tuberculosis and extensively

Lessons from the Global Fund’s fight against AIDS, Tuberculosis and Malaria

At the beginning of this century, developing countries – particularly in Africa – experienced rapidly rising illness and death from AIDS, Tuberculosis, and Malaria. The three diseases caused massive suffering and economic damage. Treatment and interventions to

20th-century version of an old pathogen. Drug resistant tuberculosis

Mycobacterium tuberculosis the causative agent of human tuberculosis (TB) is consider the most successful pathogen  that could infect (2 billion), induce (10.4 million) and kill (1.7 million) a large number of people around the world. Besides this

“Contagious and bad”. The stigma of Mycobacterial infections

Two diseases caused by mycobacteria, Tuberculosis and Leprosy, not only are they quintessential in the history of infectious diseases and humanity, but have survived the passing of the centuries still affecting millions around the world. Being present

Dormant Mycobacterium tuberculosis: a quiescent form with an eye open

Tuberculosis (TB) is the leading cause of mortality by a single pathogen in humans. Mycobacterium tuberculosis (Mtb), the etiologic agent of TB, causes millions of new cases each year. TB is an ancient disease and Mtb is

Antimicrobial peptides: the future of tuberculosis therapeutics?

Tuberculosis (TB) is a life-threatening disease that caused 1.2 million deaths, of a total 9.6 million new diagnosed cases, in 2014 alone, according to data from the World Health Organization (WHO). These data rank TB on top

Brucellosis, tuberculosis and caprine arthritis-encephalitis, are goats and sheep in El Salvador affected?

Brucellosis and tuberculosis are two animal diseases that occur in Salvadoran cattle and humans may get infected by drinking raw milk. When herds get infected for the first time with brucellosis, massive abortions in the last third

Is isoniazid so safe to use in tuberculosis preventive therapy?

Tuberculosis (TB) has emerged as a major warning to global public health as thirty three percent of the world population is considered to be infected with Mycobacterium tuberculosis (MTB)  infection.  Further, multi-drug-resistant strains of MTB in association

Automated chest X-ray screening: can edge map measure the evidence of pulmonary abnormalities?

Among many pulmonary diseases, according to the 2014 WHO report, Tuberculosis (TB) is considered as one of the deadliest communicable diseases. While TB cure rates over 90% have been documented in resource-rich countries, its detection and treatment

Truncated INH-NAD adduct, an active intermediate in the action of Isoniazid (INH) against InhA enzyme in tuberculosis

Tuberculosis (TB) remains as an important infectious disease, caused by Mycobacterium tuberculosis (MTB) which is responsible for around 1.5 million deaths and 9.6 million new cases annually. Isoniazid (INH), a bactericidal compound used as a first-line drug

The reality of latent tuberculosis bacillus?

Tuberculosis is caused by the infectious agent known Mycobacterium tuberculosis (Mtb) (Fig. 1). This rod-shaped bacterium, also called Koch’s bacillus, was discovered by Dr. Robert Koch in 1882. When a person breathes in Mtb-contaminated air, the inhaled TB bacteria

Monitoring research projects in resource-constrained countries in real-time

In under-resourced countries, paper forms are still frequently used to collect research data. Paper records are expensive to prepare, distribute, store and archive. Paper is easy to lose or destroy, and is not easy to access especially

Invertase effect localized on the cell wall on resistance of potato plants to low temperatures

Low temperature is a determinative environmental factor, which can affect all aspects of plant life and determine their geographical distribution and productivity. According to the response to low temperatures plants are divided into some groups: frost- resistant,

The social trauma of treatment resistant tuberculosis

The treatment of a man named Xiang for Treatment Resistant Tuberculosis (TRD) was previously reported within the scientific Journal of Bioethical Inquiry.  Xiang’s direct medical expenses were quoted to be in excess of $250,000 and his inability

Tuberculosis in ancient bones can also be identified by a protein of the pathogen

As we all know, DNA is the matrix for the proteins and the proteins are the molecules which are involved in every step of the metabolism of all living organisms inside and outside of cells. Without proteins

The antibacterials that have yet to be found

Science has contributed greatly to prolong the lifespan and health conditions of humans. However, close to the coming of age of the XXI Century, humankind is confronting the global war against infectious diseases. Leaving aside other microorganisms-associated

Urine lipoarabinomannan assays for paediatric tuberculosis

Tuberculosis is one of the most common infectious diseases worldwide with 2 billion people being latently infected and 9 million people diagnosed with active disease every year. Infection with TB is also a major contributor to childhood