Tag Archives: tumor

Force and morphogenesis

AoS. Somatic embryogenesis of bean from callus or tumor

Plant tissue culture has been used to propagate plants on culture media present within petri dishes. This is the propagation of plants in vitro. Using  particular plant hormones added to such media in certain concentrations, buds and

Enlightening the importance of the NDRGs in the (cancerous) gut

Enlightening the importance of the NDRGs in the (cancerous) gut. AoS

The gastrointestinal (GI) tract is one of the most complex organs of the human body. With its approximate 5m length, a diversity of specialized epithelial cell types (the ‘lining’ of the GI tract), about 80% of our

Tumor regression in a high-mortality mouse pancreatic cancer (xenograft) model with aminosteroid RM-581

Chemical representation of aminosteroid derivative. Atlas of Science

Pancreatic cancer is classified as a high-mortality cancer with a five-year relative survival rate of only 9%. Although most cancer type survival rates have improved over the past decades, pancreatic cancer morbidity has been stable, which illustrates

An integrated genomics approach for identifying breast cancer patients with highly aggressive tumors

An integrated genomics approach for identifying breast cancer patients. AoS

Breast cancer is the most common cancer in women with over 2 million new cases worldwide in 2018. Three kinds of receptors are usually found on the surface of breast cancer cells: a receptor for female hormone

Duodenal neuroendocrine tumors: what we really know about them? An Italian multicentre experience

Duodenal Neuroendocrine Tumors. AoS

Duodenal neuroendocrine neoplasms (dNENs) are heterogeneous tumors and represent up to 3% of all duodenal tumors and 2–3% of all gastrointestinal tumors. Despite clear differences, dNENs have been always treated together with either gastric neuroendocrine tumors or,

Skewed signaling through RAGE strength the tumor growth-promoting activities of M2 macrophages

Skewed signaling through RAGE strength. AoS

Tumors are complex tissues composed by both non-cellular components, mainly matrix proteins, and different stromal cell types, which are under an active cross talk with tumor cells. Tumor-associated macrophages (TAMs) are the major leukocyte population among the

Oxygen starvation promotes pro-tumorigenic cytokine expression

Oxygen Starvation Promotes Pro-Tumorigenic Cytokine Expression. AoS

Identification of the factors that trigger tumor formation and metastasis is a problem that has persisted in cancer research since its inception. To date, studies have focused on chemical signaling compounds that are part of the secretome

Wilms tumor and aneuploidy

Wilms Tumor and Aneuploidy. AoS

Wilms’ tumor or nephroblastoma is an embryological tumor of infancy that belongs to the category of “small round blue cell tumors” (Fig. 1). Such tumors are characterized by an accentuated basophilia of the nuclei with a notable

Compressed ultrasound imaging: finding tumors with a few transducers

Compressed Ultrasound Imaging with Holey Cavities. AoS

Currently, ultrasound imaging is predominantly done by a probe that possesses many transducers, which are small devices that transmit, and then receive, acoustic waves. Decreasing the number of transducers, while maintaining image quality, is surely a desirable

How to stain E-selectin ligands in tumor tissue

How to stain E-selectin ligands in tumor tissue

Cancer affects millions of people around the world. Nowadays they have more chances to survive, but still, the most frightful scenario are metastases. Few patients with metastases survive, and there is an unmet clinical need for new

Molecular targeted therapy in alveolar soft part sarcoma

Molecular Targeted Therapy in Alveolar Soft Part Sarcoma

Alveolar soft part sarcoma is a malignant and rare tumor that includes about 1% of all STS (soft tissue sarcoma), and usually occurs in adolescents and young adults. This type of cancer has tendency toward distant metastasis

Fine needle aspiration cytology for neck masses in childhood. An important tool in pediatrics

Mucin-secreting vacuolated cells, intermediate cells, and squamous cells

Neck masses can be incidental or the reason for significant concern for parents and physicians. The technique of fine-needle aspiration (FNA) cytology (FNAC) may be crucial in such settings. In 1981, the first FNA biopsy performed in

Targeting microRNAs for thyroid cancer therapy

Schematic model explaining the oncogenic actions of miR-146b and the consequences of its inhibition in thyroid cancer

The thyroid gland is a small butterfly-shaped endocrine organ located at the base of the throat, just below the Adam´s apple. Its function is to concentrate dietary iodine from the bloodstream and produce thyroid hormones, which have

Lernaean hydra puzzle in compensatory angiogenesis and tumor drug resistance

Diagrammatic representation of how compensatory angiogenic mechanisms are driven by redendent proangiogenic signalling

Before we proceed to apply the analogy of Lernaean hydra to compensatory angiogenesis and tumor drug resistance against anti-angiogenic drugs (AADs), let us have a cursory look at the interesting mythology of this hydra. According to Greek

How can we make nanoparticles more effective against cancer?

Chemotherapy is an integral part of the present cancer treatment paradigm, despite its common and severe side effects. Nanotechnology provides a plethora of promising avenues for overcoming chemotherapy limitations. Drug encapsulation within nanoparticles helps to retain it

Colorectal cancer and enteric neurons: Should tumors be nervous?

Colorectal cancer (CRC) is one of the most frequent types of cancer in the world and is associated with a high mortality rate with over 700.000 deaths per year. Throughout the past decades, the development of CRC

Curing glioblastoma with oncolytic virus and immune checkpoint blockade

Cancer immunotherapy utilizes the patient’s immune system to recognize and/or destroy tumors. The immune system has both positive activator/effector and negative inhibitory functions. Immune checkpoints are one such inhibitory function that can be overcome by immune checkpoint

Tumors of the pituitary and headache: Will it get better after surgery?

Headaches belong to the most common neurological common disorders, with many patterns of presentation, ranging from acute to chronic. Globally, the World Health Organization (WHO) estimates that half of the world’s population suffers from headache at least

The mechanisms of MCP-1 production in tumor microenvironments: Tumor cells are not home alone

When you look at tumors, you may think they are composed of 100% tumor cells. The fact is that tumor tissues contain not only tumor cells but also a variety of non-tumor stromal cells, including fibroblasts, endothelial

Osteosarcoma – lost in translation

A 16-year-old boy with pain around the knee of two months’ duration demonstrates a lesion in the epiphysis of the distal femur (long bone). The differential diagnosis may be broad, but the pathologist is able to achieve