Tag Archives: virus

Coronavirus Prevention and Detection Tools to Protect Your Health

Coronavirus Prevention and Detection Tools to Protect Your Health. AoS

More than 2.5 million cases of coronavirus had been reported as of April 22, 2020, with the death toll at more than 172,000. Of course, many more people have likely become ill and even died due to

HIV-1 alters mitochondria in neurons and contributes to HIV-associated neurocognitive disorders

HIV-1 alters mitochondria in neurons and contributes. AoS

Human immunodeficiency virus type-1 (HIV) enters the brain during the initial stages of infection and can cause neurologic dysfunction. Despite the success of HIV treatment through combination antiretroviral therapy (ART), impaired neurocognitive function remains an important problem

Dramatically distinct tropism and transduction efficiencies of AAV serotypes following subconjunctival injection

Instead of relying on traditional drug modalities, gene therapies rely on delivery of  nucleic acids into patient’s cells to prevent, slow, stop or treat diseases. In the past decades, gene therapy has been broadly studied in pre-clinical

First report describing the spatial-temporal circulation and the genetic diversity of Parapoxvirus species in Mexico

Parapoxvirus species in Mexico. AoS

The Mexican-USA Commission for the Prevention and Diagnosis of Foot and Mouth Disease laboratory (CPA) plays a critical role for the diagnosis and surveillance of animal diseases in Mexico. In this level 3 biosecurity facility foreign viral

Modeling epidemics and analyzing Ebola incidence data using Numerus Model Builder

Epidemics are quintessentially dynamic with outbreak, peak-incidence, and fadeout phases. The timings of outbreaks are hard to predict, as happened with the 2014 outbreak of Ebola viral disease in West Africa. To evaluate the risks of outbreaks,

New variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the United States

Diagram of deletion size and the location of each type of S1 NTD-del PEDV variant.

The Porcine Epidemic Diarrhea virus (PEDV) is an enveloped, positive-sense, single-stranded RNA virus that belongs to the genus Alphacoronavirus. This virus is known to only infect pigs and causes acute diarrhea, vomiting, and generally has a mortality

Engineering long-wavelength light-driven ion channels to hear the light

Artificial stimulation of the cochlea.

Optogenetics enables the remote control of neuronal activity by light. This is accomplished by channelrhodopsins, light-sensitive molecular switches, which are integrated into the neurons by adeno-associated viruses (AAVs)as gene ferries. AAVs are convenient and safe for gene

Single dose protection against lethal Ebola virus challenge

Electron micrograph showing formation of MVA-EBOV VLPs

Ebola virus disease (EVD) is a fast-progressing, highly lethal illness that poses significant threat to global public health when not contained. The current outbreak in the Democratic Republic of the Congo, as of February 26, 2019, has

Arthropod-specific viruses: where did they come from, what are they doing and where are they going?

Among the hundreds of arthropod-borne viruses (arboviruses), some, for example dengue, West Nile, and yellow fever, cause significant human infections.   Millions of infections with symptoms ranging from mild fever to fatal encephalitis occur annually.  The suffering is

A vaccine candidate for Zika with potential for reduced risk of antibody-dependent enhancement (ADE)

Zika virus (ZIKV) is a mosquito-borne flavivirus that has rapidly extended its geographic range. Its association with abnormal fetal brain development, sexual transmission, and lack of a preventive vaccine have constituted a global health concern. Designing a

Why do syringe-like nanomachines work efficiently?

Cells of living organisms widely use biological nanomachines: complex or simple systems with size less than ten millionth of a meter. Nanomachines are also used by viruses, which are the form of life that are unable to

Setting the epidemiological scenario of HCV infection in the islands of the Amazon region

Hepatitis C virus (HCV) infection is a major health problem. This viral infection is related to several serious clinical complications. About 2.2% of the world’s population is infected with HCV, most infected are asymptomatic and unconscious of

Curing glioblastoma with oncolytic virus and immune checkpoint blockade

Cancer immunotherapy utilizes the patient’s immune system to recognize and/or destroy tumors. The immune system has both positive activator/effector and negative inhibitory functions. Immune checkpoints are one such inhibitory function that can be overcome by immune checkpoint

Rapid identification of respiratory syncytial virus

Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract diseases in infancy and early childhood. A rapid, simple, and accurate plaque assay for RSV identification is one of the most important procedures in

The looming peril of neglected indigenous arbovirus infections to population expansion in Northern Australia

Viruses that are transmitted between vertebrate hosts by biting, blood-feeding arthropods (principally mosquitoes and ticks but also sandflies and midges) are called arthropod-borne viruses or, for short, arboviruses. The transmission of arboviruses to humans poses a significant and

Toscana virus circulation in central and southern Italy

Sandfly fever viruses are widely distributed in the Mediterranean basin, where they are transmitted by the bite of sandflies in the breeding season. The most common viruses associated with human infections are sandfly fever Naples virus, sandfly

How to use machine learning to discover relevant aspects in the Dengue Virus protease and guide the drug discovery process?

Dengue Virus (DENV) is perhaps one of the most relevant viral pathogens in tropical and sub-tropical areas. A World Health Organization (WHO) report indicates that DENV related infections have increased 30-fold in the last 50 years. DENV

What can computational tools tell us about one of the non-structural proteins on Zika virus?

Zika virus has come to global attention even when it only causes mild symptoms to none. Then, why WHO declared a global emergency in 2016? Beside the rapid expansion of the outbreak through Asia and Latin America,

Getting health allies from agriculture enemies

In recent years, research in nanotechnologies has demonstrated that nanometer-sized particles constructed using a wide array of materials (e.g. metals, lipids, polymers, proteins) can offer answers to unmet questions concerning drug/vaccine delivery. Ideally, these systems should prevent

Virus chainmail: protective and porous metal-organic framework grown on a virus

Biomineralization describes a process of programmable accumulation, concentration, and construction of inorganic ions regulated by organisms to form both amorphous and crystalline materials that possess well–controlled chemical components, microstructures, morphologies, and functionalities. For instance, skeletons and shells