Tag Archives: virus

Curing glioblastoma with oncolytic virus and immune checkpoint blockade

Cancer immunotherapy utilizes the patient’s immune system to recognize and/or destroy tumors. The immune system has both positive activator/effector and negative inhibitory functions. Immune checkpoints are one such inhibitory function that can be overcome by immune checkpoint

Rapid identification of respiratory syncytial virus

Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract diseases in infancy and early childhood. A rapid, simple, and accurate plaque assay for RSV identification is one of the most important procedures in

The looming peril of neglected indigenous arbovirus infections to population expansion in Northern Australia

Viruses that are transmitted between vertebrate hosts by biting, blood-feeding arthropods (principally mosquitoes and ticks but also sandflies and midges) are called arthropod-borne viruses or, for short, arboviruses. The transmission of arboviruses to humans poses a significant and

Toscana virus circulation in central and southern Italy

Sandfly fever viruses are widely distributed in the Mediterranean basin, where they are transmitted by the bite of sandflies in the breeding season. The most common viruses associated with human infections are sandfly fever Naples virus, sandfly

How to use machine learning to discover relevant aspects in the Dengue Virus protease and guide the drug discovery process?

Dengue Virus (DENV) is perhaps one of the most relevant viral pathogens in tropical and sub-tropical areas. A World Health Organization (WHO) report indicates that DENV related infections have increased 30-fold in the last 50 years. DENV

What can computational tools tell us about one of the non-structural proteins on Zika virus?

Zika virus has come to global attention even when it only causes mild symptoms to none. Then, why WHO declared a global emergency in 2016? Beside the rapid expansion of the outbreak through Asia and Latin America,

Getting health allies from agriculture enemies

In recent years, research in nanotechnologies has demonstrated that nanometer-sized particles constructed using a wide array of materials (e.g. metals, lipids, polymers, proteins) can offer answers to unmet questions concerning drug/vaccine delivery. Ideally, these systems should prevent

Virus chainmail: protective and porous metal-organic framework grown on a virus

Biomineralization describes a process of programmable accumulation, concentration, and construction of inorganic ions regulated by organisms to form both amorphous and crystalline materials that possess well–controlled chemical components, microstructures, morphologies, and functionalities. For instance, skeletons and shells

Epstein Barr Virus (EBV) infection empowers B lymphocytes for autoimmunity

The human body is under constant threat of foreign invaders (bacteria, viruses, parasites) that can cause infectious diseases. The reason why this often does not occur is the immune system, a complex collection of molecules and cells

How realistic is the potential global spread of Zika virus and should we all be worried?

Unless you have taken a holiday on Mars for the whole of this year no doubt by now you will have heard of Zika. This is the virus that has emerged in the last 18 months to

Zika virus infection during pregnancy and small heads: What is the connection and what can be seen by imaging

Within the last year, the outbreak of Zika virus infection in Brazil became a “public health emergency of international magnitude and concern”. The global discussions about the risk of Zika virus infection for pregnant women ahead of

Is there any association between immunosuppressant therapy and cancer related to HPV in men? Can we prevent it?

We reported a rare case of penile squamous carcinoma and inguinal metastasis in a patient with ulcerative colitis under azathioprine for many years. We could identify in the histogical study the presence of 16 and 18 HPV

Varicella. A case report: With palms and sole of foot affectation

Varicella is caused by Varicella Zoster Virus (VVZ). This virus produces two different clinical manifestations of diseases: varicella and herpex zoster. It is present all over the world. In children, varicella is a mild disease, but in

Not in my neighborhood- herpes simplex virus control of microbiome locality

The players vary, but who is really controlling occupancy of the host mucosal surfaces? The host may no longer be the sole ruling factor controlling the receptor sites for attachment of microbes, and thus membership in the

Immunogenicity of Virus Like Particles (VLP) with modified envelope (Env) protein

HIV uses a special strategy to evade the immune system during the course of infection in a human, based on features of envelope protein.  The HIV Env glycoprotein that forms spikes on the surface of virus particles

Do doctors understand what helps patients with hepatitis C stay on and complete their treatment?

To be cured of hepatitis C, patients must take their medications as prescribed without missing doses and complete the full course of treatment. However, almost half of patients with hepatitis C find it difficult to take their