Tag Archives: virus
What Is The Role Of GMP In Ensuring Quality Viral Vector Production?
Viral vectors have revolutionized modern medicine by enabling the delivery of therapeutic genes and the development of advanced vaccines. To ensure that viral vectors are safe, effective, and suitable for clinical and commercial use, Good Manufacturing Practices
Atmospheric and genetic parameters influence Rhinovirus transmission
Rhinoviruses are a diverse set of very small and common viruses, repeatedly infecting humans in the course of a single year. For most people, infection usually results in mild common cold symptoms, and spontaneously resolves without the
Any cell organelle can be the starting point for toxicant and pathogen-induced cell death
Toxicants and pathogens often induce death of their target and host cells. In order to investigate the different ways they can achieve this I have used the hepatopancreatocytes of decapod crustaceans as an example, Specifically, I tried
Coronavirus Prevention and Detection Tools to Protect Your Health
More than 2.5 million cases of coronavirus had been reported as of April 22, 2020, with the death toll at more than 172,000. Of course, many more people have likely become ill and even died due to
HIV-1 alters mitochondria in neurons and contributes to HIV-associated neurocognitive disorders
Human immunodeficiency virus type-1 (HIV) enters the brain during the initial stages of infection and can cause neurologic dysfunction. Despite the success of HIV treatment through combination antiretroviral therapy (ART), impaired neurocognitive function remains an important problem
Dramatically distinct tropism and transduction efficiencies of AAV serotypes following subconjunctival injection
Instead of relying on traditional drug modalities, gene therapies rely on delivery of nucleic acids into patient’s cells to prevent, slow, stop or treat diseases. In the past decades, gene therapy has been broadly studied in pre-clinical
First report describing the spatial-temporal circulation and the genetic diversity of Parapoxvirus species in Mexico
The Mexican-USA Commission for the Prevention and Diagnosis of Foot and Mouth Disease laboratory (CPA) plays a critical role for the diagnosis and surveillance of animal diseases in Mexico. In this level 3 biosecurity facility foreign viral
Modeling epidemics and analyzing Ebola incidence data using Numerus Model Builder
Epidemics are quintessentially dynamic with outbreak, peak-incidence, and fadeout phases. The timings of outbreaks are hard to predict, as happened with the 2014 outbreak of Ebola viral disease in West Africa. To evaluate the risks of outbreaks,
New variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the United States
The Porcine Epidemic Diarrhea virus (PEDV) is an enveloped, positive-sense, single-stranded RNA virus that belongs to the genus Alphacoronavirus. This virus is known to only infect pigs and causes acute diarrhea, vomiting, and generally has a mortality
Engineering long-wavelength light-driven ion channels to hear the light
Optogenetics enables the remote control of neuronal activity by light. This is accomplished by channelrhodopsins, light-sensitive molecular switches, which are integrated into the neurons by adeno-associated viruses (AAVs)as gene ferries. AAVs are convenient and safe for gene
Single dose protection against lethal Ebola virus challenge
Ebola virus disease (EVD) is a fast-progressing, highly lethal illness that poses significant threat to global public health when not contained. The current outbreak in the Democratic Republic of the Congo, as of February 26, 2019, has
Arthropod-specific viruses: where did they come from, what are they doing and where are they going?
Among the hundreds of arthropod-borne viruses (arboviruses), some, for example dengue, West Nile, and yellow fever, cause significant human infections. Millions of infections with symptoms ranging from mild fever to fatal encephalitis occur annually. The suffering is
A vaccine candidate for Zika with potential for reduced risk of antibody-dependent enhancement (ADE)
Zika virus (ZIKV) is a mosquito-borne flavivirus that has rapidly extended its geographic range. Its association with abnormal fetal brain development, sexual transmission, and lack of a preventive vaccine have constituted a global health concern. Designing a
Why do syringe-like nanomachines work efficiently?
Cells of living organisms widely use biological nanomachines: complex or simple systems with size less than ten millionth of a meter. Nanomachines are also used by viruses, which are the form of life that are unable to
Setting the epidemiological scenario of HCV infection in the islands of the Amazon region
Hepatitis C virus (HCV) infection is a major health problem. This viral infection is related to several serious clinical complications. About 2.2% of the world’s population is infected with HCV, most infected are asymptomatic and unconscious of
Curing glioblastoma with oncolytic virus and immune checkpoint blockade
Cancer immunotherapy utilizes the patient’s immune system to recognize and/or destroy tumors. The immune system has both positive activator/effector and negative inhibitory functions. Immune checkpoints are one such inhibitory function that can be overcome by immune checkpoint
Rapid identification of respiratory syncytial virus
Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract diseases in infancy and early childhood. A rapid, simple, and accurate plaque assay for RSV identification is one of the most important procedures in
The looming peril of neglected indigenous arbovirus infections to population expansion in Northern Australia
Viruses that are transmitted between vertebrate hosts by biting, blood-feeding arthropods (principally mosquitoes and ticks but also sandflies and midges) are called arthropod-borne viruses or, for short, arboviruses. The transmission of arboviruses to humans poses a significant and
Toscana virus circulation in central and southern Italy
Sandfly fever viruses are widely distributed in the Mediterranean basin, where they are transmitted by the bite of sandflies in the breeding season. The most common viruses associated with human infections are sandfly fever Naples virus, sandfly
How to use machine learning to discover relevant aspects in the Dengue Virus protease and guide the drug discovery process?
Dengue Virus (DENV) is perhaps one of the most relevant viral pathogens in tropical and sub-tropical areas. A World Health Organization (WHO) report indicates that DENV related infections have increased 30-fold in the last 50 years. DENV
