The glycated hemoglobin test gives the information about average level of blood sugar over the past 2 to 3 months. It’s also called HbA1c, glycated hemoglobin test, and glycohemoglobin. Persons who have diabetes require this test regularly to see if their levels are staying within range. The glucose level measurement in the diabetic patient plays a vital role in identification of the treatments going on and it also provides the control over the diabetics.

A new electrochemical sensing device was constructed for determination of HbA1c in whole blood samples. Fructosyl amine oxidase (FAO) was bioconjugated onto hybrid nanocomposite i.e., gold nanoparticles-platinum nanoparticles (AuNPs-PtNPs) and poly indole-5-carboxylic acid (PIN5COOH), deposited electrochemically on gold electrode. Bimetallic nanoparticles not only show their individual properties but also provides the synergistic effect between the two noble metal nanoparticles. AuNPs-PtNPs shown as an amplified sensing interface at lower voltage which makes the sensor more sensitive and specific.

The FAO/AuNPs-PtNPs onto PIN5COOH/Au electrode shows a promising future in diagnosis of HbA1c and diabetes management. The novel sensor formed has good accuracy, selectivity, sensitivity, precision and reliability. In addition to these, it showed good storage stability and retained 50% of its initial activity within 12 weeks at 4°C.

Nidhi Chauhan
Amity Institute of Nanotechnology (AINT), Amity University, Noida, India

Publication

Construction of an amperometric glycated hemoglobin biosensor based on Au-Pt bimetallic nanoparticles and poly (indole-5-carboxylic acid) modified Au electrode.
Jain U, Gupta S, Chauhan N
Int J Biol Macromol. 2017 Dec

Read offline:     

Related Articles:

	Magnetic chitosan hydrogel: a good choice for… Hydrogels as three-dimensional polymeric networks have been of longstanding interest due to their biocompatibility, hydrophilic nature, desired functionality, high elasticity, and superb capacities for retaining large amount of water and…
	Ti3C2-MXene based fluorescent biosensor for rapid… Over the last decade, zero-dimensional (0D) and two-dimensional (2D) nanomaterials such as nanostructured metals, and graphene derivatives delivered an extraordinary impact as fluorescence quenchers or energy acceptors in developing fluorescent…
	Your pharmacist will see you now! Public perception of pharmacists might be limited to dispensing medications. However, pharmacists are trained to deliver patient care to help patients improve their health-related outcomes and achieve their goals. Recognizing…
	Am I at risk of developing diabetes if exposed to… The answer is: it depends. Of course, there is no trivial answer to an open question like that when referring to scientific investigation. But we can make you think better…
	Is milk and meat from the offspring of a bull genome… Horns on cattle are an animal welfare and human safety concern, but most high producing dairy breeds grow horns. Introducing the polled (hornless) trait into the dairy population by crossbreeding…
	Exercise inhibits cancer: the mechanosensitive state… Surprisingly, researchers find that tumor cells are sensitive to mechanical stresses. This may provide new ways to treat cancers without the severe side-effects of many therapies. Because mechanosensitivity of cancer…