Bimetallic nanoparticles-based biosensor for managing diabetes
The glycated hemoglobin test gives the information about average level of blood sugar over the past 2 to 3 months. It’s also called HbA1c, glycated hemoglobin test, and glycohemoglobin. Persons who have diabetes require this test regularly to see if their levels are staying within range. The glucose level measurement in the diabetic patient plays a vital role in identification of the treatments going on and it also provides the control over the diabetics.
A new electrochemical sensing device was constructed for determination of HbA1c in whole blood samples. Fructosyl amine oxidase (FAO) was bioconjugated onto hybrid nanocomposite i.e., gold nanoparticles-platinum nanoparticles (AuNPs-PtNPs) and poly indole-5-carboxylic acid (PIN5COOH), deposited electrochemically on gold electrode. Bimetallic nanoparticles not only show their individual properties but also provides the synergistic effect between the two noble metal nanoparticles. AuNPs-PtNPs shown as an amplified sensing interface at lower voltage which makes the sensor more sensitive and specific.
The FAO/AuNPs-PtNPs onto PIN5COOH/Au electrode shows a promising future in diagnosis of HbA1c and diabetes management. The novel sensor formed has good accuracy, selectivity, sensitivity, precision and reliability. In addition to these, it showed good storage stability and retained 50% of its initial activity within 12 weeks at 4°C.
Amity Institute of Nanotechnology (AINT), Amity University, Noida, India
Construction of an amperometric glycated hemoglobin biosensor based on Au-Pt bimetallic nanoparticles and poly (indole-5-carboxylic acid) modified Au electrode.
Jain U, Gupta S, Chauhan N
Int J Biol Macromol. 2017 Dec
|Magnetic chitosan hydrogel: a good choice for… Hydrogels as three-dimensional polymeric networks have been of longstanding interest due to their biocompatibility, hydrophilic nature, desired functionality, high elasticity, and superb capacities for retaining large amount of water and…|
|Ti3C2-MXene based fluorescent biosensor for rapid… Over the last decade, zero-dimensional (0D) and two-dimensional (2D) nanomaterials such as nanostructured metals, and graphene derivatives delivered an extraordinary impact as fluorescence quenchers or energy acceptors in developing fluorescent…|
|Nutritional strategies in managing postmeal glucose… The postmeal hyperglycemia is a common feature of Type 2 Diabetes (T2D) with the majority of the patients have not achieved the postmeal target of less than 7.8 mmol/L at…|
|Chronic unpredictable environmental stress is… Stress refers to the mental and emotional change of state from normal homeostasis. In another words we can say that stress happens when we are worried for something and feeling…|
|Rapid monitoring of the impact of polymicrobial… The development of bacterial infections is a major challenge as pathogenic bacteria spread through healthcare facilities where patients may come in contact with complex bacterial communities heavily colonizing on hospital…|
|Intestinal inflammation mediated by silver… The interest in silver nanoparticles (AgNP) has been growing exponentially around the world, due to their unique physical, chemical and biological properties, as evidenced by their wide application in numerous…|