Tag Archives: 3GC base pairs

Unraveling multiple checkpoints for accurate selection of initiator tRNA on ribosomes for translation initiation

Ribosomes comprise a large (50S) and a small (30S) subunits. To begin (initiate) protein synthesis, the two subunits associate on an mRNA (70S). Organisms possess two classes of tRNAs, the initiators (i-tRNA) and the elongators. The i-tRNA