Tag Archives: FRET

Do you want a specific signal? Go local! Imaging our way to targeted therapy

Cyclic adenosine monophosphate (cAMP) is a ubiquitous intracellular second messenger, a small molecule that conveys the information carried by hormones, neurotransmitters and other extracellular stimuli to the intracellular environment. cAMP is generated at the plasma membrane when

Novel biophysical assay reveals that bacterial cell wall maintaining proteins change interaction conformation based on activity

Bacterial infections are increasingly difficult to treat with antibiotics due to antibiotic resistance. Knowledge on how of bacteria multiply needs to be profoundly expanded as a requirement for the development of new methods for the discovery of

Assaying protein-protein interaction by the complementation of firefly luciferase catalytic steps

Protein – protein interaction (PPI) assay is a key technology for various fields from basic molecular biology to diagnosis and drug discovery. Previously, PPI assays based on fluorescence resonance energy transfer (FRET), bioluminescence resonance energy transfer (BRET)

White light emissive molecular siblings

Human eye is capable of detecting only a relatively tiny part of the electromagnetic spectrum. However limited our vision might be, it is filled with the experiences of numerous colors, colors that control our emotional responses.  White-light

Harnessing Förster energy transfer

Our fascination with light, matter and their mutual interactions has been the driving force behind the advent of new optical materials, ranging from a variety of organic and inorganic dielectrics to tailored metals, photonic crystals and more

Fluorescent micro-RNA for cancer diagnostics

Biomarkers are indicators of biological states or conditions and can therefore provide important information about diseases such as cancer. In clinical diagnostics biomarkers are most often proteins or nucleic acids such as DNA or RNA. Biomarkers that