Tag Archives: PARP
A new link between oxidant stress and lung cancer
DNA repair protects our cells from conditions that cause damage to the genome, which can become a threat to the maintenance and function of our tissues. Our cells have a variety of DNA repair systems. Most frequent
How to detect dying neurons in the central nervous system?
The central nervous system (CNS) changes dynamically throughout an animal life. In the fruit fly, Drosophila melanogaster, asymmetric mitosis of the neuroblasts during embryonic development produces about 10,000 differentiated neurons that form a juvenile (larva) CNS. These
The TMPRSS2-ERG fusion gene radiosensitizes to PARP inhibition by blocking DNA repair
Radiotherapy, which is used widely in the clinic, produces DNA damage that leads to DNA double-strand breaks (DSBs). The effectiveness of radiotherapy is augmented when the DNA repair is impaired. TMPRSS2-ERG is a unique fusion gene that