Tag Archives: SB-334867

Orexin signaling promotes initial alcohol consumption

AoS. Orexin signaling promotes initial alcohol consumption

Orexins (orexin-A, orx-A and orexin-B, orx-B) are neuropeptides expressed exclusively in hypothalamic neurons of the lateral hypothalamus and perifornical area. They mediate their effects through activation of two G-protein coupled receptors, the orexin-1-receptor (Orx1R) and orexin-2-receptor (Orx2R).