Daily Archives: June 24, 2019

Mitochondrial Complex I activity signals antioxidant response through ERK5

Mitochondrial Complex I activity signal

The vast majority of eukaryotic cells perform oxidative phosphorylation (OXPHOS), which uses the energy released by the mitochondrial oxidation of certain metabolites, i.e. glucose, to produce adenosine triphosphate (ATP). OXPHOS is highly efficient in energy production but

Adult-onset biotinidase deficiency

Adult-onset Biotinidase deficiency

Biotinidase is the enzyme that recycles the water-soluble vitamin, biotin, which is the coenzyme for four carboxylases that are involved in gluconeogenesis, fatty acid synthesis, and in the catabolism of several branch-chain amino acids. Biotinidase deficiency (BD)