Category Archives: Research

Parkinson disease: a tale of three neurotransmitters

The progressive loss of dopaminergic innervation of the basal ganglia, in particular of the dorsal striatum (putamen) is responsible for the motor signs of Parkinson disease such as bradykinesia, rigidity and loss of postural reflexes. Present therapies

No-bonding reactivity of Helium under pressure

The 1D model of He insertion into AB and A2B compounds

Noble gas (NG) elements have been thought historically to be chemically inert. Nevertheless, already in 1930, Pauling predicted that Xenon could react with other elements. Thirty years later, Bartlett synthetized the first Xe compound, Xe+[PtF6]–. High pressure

Disengaging ATF6 from DREAM for neuroprotection

Disengaging ATF6 from dream for neuroprotection

To study early changes in neuronal function during the pre-symptomatic phase of a given neurodegenerative disease is very important. It could deliver early diagnostic markers, offer prognostic clues about disease progression and uncover novel therapeutic targets for

Grandmothers’ breastfeeding stories to mothers: a knowledge translation gift


Breastfeeding is an ideal way to feed babies that promotes and protects health throughout life. In the Northwest Territories, Canada, in follow-up to a study from one region of the territory, we conducted a territory-wide study to

Therapeutic delivery vehicle development by combinatorial post-modification

Schematic illustration of combinatorial polymer libraries synthesized by post-modification of reactive polymers for the optimization of therapeutic delivery polymers.

Polymers are widely used in the construction of nanocarriers for therapeutic delivery because of their precisely controllable structure and low toxicity. Combinatorially modified polymers usually have a portion of similar structures, while other specific structures determine the

Subjects with gambling-related problems requiring treatment

Subjects with Gambling-Related Problems Requiring Treatment

Gambling disorders affect 0.2–5.3% of adults worldwide, although measurement and prevalence varies according to the screening instruments and methods used, and the availability and accessibility of gambling opportunities. A significant percentage of gamblers develops clinically relevant gambling

Oral corticosteroids on hand to treat the next asthma exacerbation?

Outcome of asthma the years before and after oral corticosteroids were provided to parents for treatment of the next exacerbation.

Asthma exacerbations are a major cause of visits to an emergency room, especially for children. What is an asthma exacerbation? There is general agreement that acute symptoms of asthma become an exacerbation when they are more frequent

An educational programme for the control of hospital outbreaks

Healthcare associated infections due to microorganisms resistant to multiple antimicrobial drugs (Multidrug Resistant Organisms-MDROs) represent a concern for healthcare facilities worldwide. Because of the difficulties in the management of MDRO infections, various guidelines containing recommendations have been

Diagnostic challenges between Chiari malformation and neurocysticercosis

The development of hydrocephalus with reaccumulation of fluid in the surgical site.

Diagnosis of neurocysticercosis can be challenging due to a wide variety of symptoms depending on the location, developmental stage, and the number of cysts when symptomatic. However, uninflamed extraparenchymal cysts are isodense to cerebrospinal fluid and may

Improving outcomes after liver transplantation using body-temperature organ preservation

OrganOx metra(TM) normothermic liver perfusion device

The global shortage of livers for transplantation has necessitated the use of increasingly marginal organs. Many countries have seen a recent increase in deceased organ donors but many of these additional donors are sub-optimal with significant co-morbidities,

Bacteriocin AS-48: a potent drug against sleeping sickness

Graphical abstract about AS-48 activity against Trypanosoma brucei.

African trypanosomiasis has been a historical scourge on the African continent and one of the major causes of poverty. It is responsible for sleeping sickness in humans (HAT), and it avoids the development of agriculture based on

Percutaneous axillary artery access for fenestrated and branched thoracoabdominal endovascular repair

Percutaneous axillary artery access for fenestrated and branched thoracoabdominal endovascular repair

An upper extremity access (UEA) is necessary for complex endovascular aortic repairs, especially for branched and fenestrated endografts to successfully catheterize target vessels with a caudal orientation. The subclavian artery and axillary artery (AxA) have largely been

Brain networks in major depressive disorder

Pathophysiology of major depressive disorder (MDD) is poorly understood, because it affects a broad range of motivational, emotional, and cognitive processes, which are difficult to disentangle. Thus, task performance differences between patients and healthy controls may relate

Multiple sclerosis diagnosis from cerebrospinal fluids via infrared spectroscopy with chemometrics

Multiple sclerosis (MS) is a chronic, demyelinating and degenerative disease of central nervous system (CNS), characterized by an autoimmune inflammation. Approximately 2.5 million people in the world are affected from multiple sclerosis which is one of the

Targeting cholesterol metabolism to suppress prostate cancer metastasis

Targeting cholesterol metabolism to suppress prostate cancer metastasis

Metastatic prostate cancer is the second leading cause of cancer death in men worldwide. Prostate cancer itself is one of the most common cancers in men. At the early stages, localized prostate cancer usually grows slowly and

Physics of the mechanical toy Gee-Haw Whammy Diddle

Gee-haw whammy diddle is a mechanical toy consisting of two wooden rods and a propeller. The main rod has a series of notches engraved in it and a propeller loosely attached to its end. The driving rod

Toward more accessible PET imaging: Miniaturizing the last step of radiotracer preparation

Toward more accessible PET imaging

Positron emission tomography (PET) is a 3D body imaging method for visualizing dynamic biochemical processes in living subjects with unparalleled specificity and sensitivity. PET scans, often performed together with CT or MRI imaging, are used clinically to

Health damage of smoking among Palestinian men in the West Bank

Life expectancy and expected life time without and with chronic disease at age 15. Men, West Bank, 2010

The high smoking prevalence of more than 40 % among men living on the West Bank of the occupied territories is a major challenge for the Palestinian health authorities although the prevalence is lower in the Gaza

New literacy challenge: genetic knowledge is poor even among well educated

genome, genetic testing, genetic literacy, genetic discrimination

The beginning of the 21st century marked the beginning of the genomic era and of a new literacy challenge – genetic literacy. From genes we can now extract information related to all aspects of peoples’ lives. This

Prescription opioid use underestimated in the United States

The opioid epidemic continues to have many negative effects in the US. The US lifespan has been decreasing and opioid overdoses are believed to be responsible. Other consequences of opioid misuse include the increases in emergency room