Category Archives: Research
The development of bacterial infections is a major challenge as pathogenic bacteria spread through healthcare facilities where patients may come in contact with complex bacterial communities heavily colonizing on hospital surfaces. These bacteria cause internal and external
Macroautophagy (hereafter autophagy) is the main intracellular degradation mechanism to maintain cellular homeostasis by degrading misfolded proteins, recycling dysfunctional organelles, and generating energy fuels under physiological and pathological conditions. Autophagy consists of two major steps: autophagosome formation,
Novel genetics approach identifies GNAS gene as an important prerequisite for β-cell secretory capacity
Type 2 diabetes mellitus (T2D) is a major health burden in developing and industrialized countries (www.idf.org). Common genetic variations, susceptibility genes, epigenetic regulation, and miRNAs have been suggested to be profoundly involved in the pathogenicity of T2D.
Accelerated soil erosion and loss is a serious environmental problem, particularly for the Mediterranean region, due to its long history of human pressures, seasonally contrasting climate and rugged topography. Anthropogenic activities such as agriculture, deforestation, urbanization and
Acute inflammation is a localized, self-limited host defense mechanism against invading microorganism and tissue injury. Rapid recruitment of white blood cells called neutrophils (polymorphonuclear neutrophil granulocytes) from the blood to the site of infection or injury is
Cancer of the prostate gland is a common malignancy afflicting males worldwide. This cancer is the second deadliest amongst male in United States, with most of the mortality resulting from aggressive, advanced stage, metastatic disease. Prostate cancer
Cartilage in the knee does not heal very well nor very quickly, so continued use of the leg when walking for example can result in further damage, bony projections (osteophytes), stiffening and swelling of the joint (Fig.
Light-emitting diodes (LEDs) are fundamental devices for backlights and displays. Nowadays, three different-color epitaxial chips are mainly applied in an RGB pixel: Blue, green, and red LED chips. However, it is difficult to further improve the color
Edible olives and the production of olive oil dates to 5000 BC and, nowadays, it is estimated to occupy an area of 10.2 million hectares. More than 90% of the total area is in the Mediterranean Basin.
Volatile methyl siloxanes (VMS) are man-made compounds containing silicon and oxygen with organic side groups (typically methyl groups) attached to the silicon atoms. Siloxanes can have linear (denoted by L or M nomenclature) and cyclic (denoted by
Gastrointestinal stromal tumor transition to KIT-independence is enabled by a Cyclin D1 dependent proliferation program
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. GISTs generally contain oncogenic gain-of-function KIT (~85%) or PDGFRA (~5-10%) mutations which are crucial for GIST proliferation and survival, as underscored by the
Fibroblasts are cells that synthesize collagen and support the maintenance of connective tissue in the skin, tendons, and joints. They maintain a critical role in the immune system’s response to tissue injury by promoting wound healing at
Cryo-EM has established its position in structural biology as an indispensable method of choice for determining macromolecular structures due to recent technological breakthroughs. The recent years have observed a steep increase of biomolecular structures solved by cryo-EM,
The thermotherapy is a useful approach in medical field, such as hyperthermia, laser soldering, laser ablation, laser surgery and other thermal treatment methods. In order to maximize the therapeutic efficiency while ensuring the patients’ safety, the thermal
Recent advances in high-throughput biotechnologies, such as microarray and sequencing technologies, have provided an unprecedented opportunity for biomarker discovery, which potentially enhances the development of precision medicine. From a statistical point of view, the discovery of biomarkers
Up to 12% of the U.S. population will be diagnosed with a thyroid condition. Because thyroid hormones affect every cell in the body, hypo- (low) and hyper-(high) thyroidism can be difficult to distinguish from other medical conditions.