Do metals in pregnant women have association to preterm births?
Metals are widely distributed in the environment. Recent reports have demonstrated the risk of preterm birth following heavy metal exposure. Preterm births include those occurring before 37 completed weeks of pregnancy, and the rate of preterm births is increasing in almost all countries. Preterm births are divided into several groups. For example, preterm births are classified as early (< 34 weeks) and late (34 to < 37 weeks). Early preterm babies are at a higher risk of mortality, heart failure, immunologic/infectious morbidities and disabilities. In addition, preterm birth is a burden not only to the health of newborns, but also to that of the mothers. It is thus necessary to investigate whether metal exposure in fact affects preterm birth, especially early preterm birth, and if so, which metals strongly influence preterm births in order to protect the health of both mothers and babies.
Therefore, we analyzed the association between maternal whole blood concentrations of metals, such as cadmium (Cd), lead (Pb), mercury (Hg), selenium (Se), and manganese (Mn) that are common toxicants in Japan, and preterm births.
The data of 14,847 pregnant women who were participants of the Japan Environment and Children’s Study (JECS) were used. Data of the self-questionnaire pertaining to the first trimester (T1), second/third trimester (T2), and medical records after delivery were analyzed. We divided preterm birth into two groups: early preterm (22 to < 34 weeks) and late preterm (34 to < 37 weeks). Maternal blood samples for measuring metal concentrations were collected in T2. The participants were classified into four quartiles (Q1–Q4) according to increasing metal levels.
The rate of preterm birth was 4.5%. After controlling for confounding factors, such as age, pre-pregnancy body mass index, smoking, partner’s smoking, drinking habits, gravidity, parity, number of cesarean deliveries, uterine infections, household income, educational levels, and sex of infant, Cd levels were found, by multivariable logistic regression analysis, to be significantly associated with early preterm birth, with odds ratio for early preterm birth of 1.91 (95% confidence interval: 1.12–3.27, P = 0.018) in subjects of Q4 compared with in subjects with term birth (≧ 37 weeks). In other words, there was a relationship between high whole blood concentrations of Cd in pregnant women and risk of early preterm births, but no relationship between Cd concentration and risk of late preterm births.
This is the first study to analyze the relationship between multiple metal concentrations and early and late preterm births in a large-scale cohort. Identification of the main sources of Cd and reductions of maternal Cd exposure may contribute to the prevention of early preterm births and health maintenance of mothers and their infants in the future.
Mayumi Tsuji
Department of Environmental Health, University of Occupational and Environmental Health, Japan
Publication
The association between whole blood concentrations of heavy metals in pregnant women and premature births: The Japan Environment and Children’s Study (JECS).
Tsuji M, Shibata E, Morokuma S, Tanaka R, Senju A, Araki S, Sanefuji M, Koriyama C, Yamamoto M, Ishihara Y, Kusuhara K, Kawamoto T; Japan Environment & Children’s Study Group
Environ Res. 2018 Oct
Related Articles:
![]() | Late second trimester miscarriages A second trimester miscarriage is the spontaneous loss of a pregnancy between 12 and 22 weeks of pregnancy. This is indeed a very sad experience to the parents. It has… |
![]() | Am I at risk of developing diabetes if exposed to… The answer is: it depends. Of course, there is no trivial answer to an open question like that when referring to scientific investigation. But we can make you think better… |
![]() | No adverse outcomes for infants associated with mums… What is whooping cough, or pertussis? Whooping cough, or pertussis, is a highly contagious bacterial respiratory infection that can be very serious for young infants. Symptoms include violent coughing fits… |
![]() | Mortality risk among cocaine users after and before… This study targeted residents in northern Italy who turned to a public treatment centre for primary cocaine use between 1982 and 2016. Its aims were to estimate mortality risk, and… |
![]() | T-cell subsets in HIV infection The human immunodeficiency virus (HIV) is a virus that assaults the body's immunologic system. If HIV is not tackled, it can eventually drive the organism to AIDS, which a dreadful… |
![]() | Waking a sleeping giant: How increasing Africa's… Africa is home to 1.4 billion people, of whom 55 million suffer from cardiovascular disease (CVD). Despite this, Africa contributes to only 1.7% of the world’s cardiovascular science. We studied… |
Leave a Reply
You must be logged in to post a comment.