Licorice Root enhance cardiovascular health

The increasing incidence of lifestyle-based conditions–most notably those conditions that impact cardiovascular health, obesity, and blood sugar–has compelled consumers to consider natural solutions for these challenges. According to the Centers for Disease Control and Prevention (CDC), cardiovascular events are a leading cause of death in the United States.  And cardiovascular disease can impact people of all ages and backgrounds.

More and more consumers realize that a preventive approach to their health will promote both longevity and quality of life.  And natural products are becoming a significant part of the protocol.

Cholesterol oxidation in the arteries causes buildup of plaque, which, in turn, causes the arteries to narrow, increasing the risk for a cardiovascular event. Although the process is complex, health professionals believe that oxidation starts slowly when certain factors damage the inner layers of the arteries. Over time, the arteries harden and begin to narrow, which restricts the normal flow of fresh, oxygen-rich blood.

Keep in mind that as you age, developing high cholesterol and other risk factors is inevitable. There are healthy lifestyle habits, including eating a good diet, exercise, and maintaining a healthy weight that can help reduce the risk. The good news is that certain dietary supplements really do promote cardiovascular health – and have been clinically validated.

New breakthrough for combating cardiovascular oxidation
In recent months, biotechnology company Allied BioNutrition, has unveiled a relatively unknown ingredient  that provides compelling antioxidant properties and powerful cardiovascular health benefits. The ingredient is Licorice Root, in the form of a unique extract that comes from this natural ingredient.

Recently, the results from Allied BioNutrition’s double-blind, placebo-controlled study were published in the scientific journal Food and Nutrition Research.  The study examined the effect of a unique licorice-root extract on the thickness of the artery wall (carotid intima-media thickness or CIMT) in individuals with increased oxidation in the arteries.  CIMT is considered a strong biomarker of overall cardiovascular and arterial health.

People with increased oxidation, total cholesterol greater then 240mg/dl, were randomly allocated to 2 groups as follows: an experimental group that received 200mg of the licorice root extract and a placebo group.  110 participants were initially allocated to the 2 groups.  After some withdrawals, 94 subjects ultimately completed the trial.  After 1 year, the study yielded the following results:

  • In the experimental group the thickness of artery (CIMT) decreased from 0.92 mm to 0.84 mm. In the placebo group CIMT increased from 0.85 to 0.88.
  • In the experimental group total cholesterol decreased from 284 to 262 mm/dL. In the placebo group total cholesterol decreased from 291 to 289mm/dL
  • In the experimental group, the LDL (bad) cholesterol decreased from183 to 173 mm/ dL. In the placebo group, the LDL (bad) cholesterol increased from 177 to 179.
  • HDL or good cholesterol did not change in either group
  • In the experimental group systolic blood pressure decreased from 138 to 125mmhg. In the placebo group, systolic blood pressure increased from 136 to 137.
  • In the experimental group diastolic blood pressure decreased from 92 to 84. In the placebo group diastolic blood pressure increased from 89 to 90.

These results were extremely compelling. Following one year of licorice root extract consumption, mean CIMT, total cholesterol, LDL levels, and blood pressure decreased. This suggests that this ingredient may attenuate the development of oxidation and of related cerebral vascular issues.

Yacov Fogelman
The Ruth & Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Biotechnology company Allied BioNutrition



Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: decreased CIMT, reduced plasma lipid levels, and decreased blood pressure.
Fogelman Y, Gaitini D, Carmeli E
Food Nutr Res. 2016 Apr 22


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