Tag Archives: amyloid

Cholesterol manipulation switches the production of “toxic Aβ” to “protective Aβ”

The amyloid hypothesis maintains that the pathogenesis of Alzheimer’s disease (AD) is driven by the production and accumulation of amyloid-β (Aβ) peptides in the brain. Consequently, many therapeutic strategies to reduce Aβ production have been examined. However,

DNAJB6 – an early-stage scavenger of amyloidogenic peptides

A molecular chaperone has been discovered that binds to amyloidogenic peptides and delays onset of aggregation and neurodegeneration. Chaperone proteins, existing in the cells of all organisms, are helper proteins that serve to keep the proteins in

Visualizing gelsolin amyloid with nanobodies; small molecules with big potential

Amyloidosis is a group of diseases characterized by the deposition of aggregated proteins, or protein fragments, in tissues and organs. The diseases differ from each other in the causative protein, but once aggregation starts, they all result

Sick arteries give their small cousins a beating: new insight into vascular pathology in Alzheimer’s disease

That the brain’s blood vessels, a.k.a. cerebrovasculature, play an important role in Alzheimer’s disease (AD) and related brain disorders is not entirely new. In fact, it was Alois Alzheimer and some of his contemporaries who observed gross

Possible mechanisms of amyloid growth

At present there is no consensus whether a protofilament is formed by joining oligomers or by adding monomers. The following questions can be posed: How many different mechanisms exist in the literature to describe the protein aggregation?

Small or big, brain cells don’t like protein gunk that lead to diseases like Alzheimer’s, Parkinson’s and Huntington’s

An interdisiciplinary study by scientists at Trinity College Dublin (TCD, Ireland) have answered a hotly debated question in the neurodegenerative diseases research area: “Which protein aggregate form is the primary pathogenic agent in neurodegenerative diseases – (i) the prefibrillar oligomeric