Tag Archives: B cells

Anti-CD20 treatment shows changes not only in B-lymphocytes but also in T-subpopulations

In renal pathology, Rituximab has been proven to be useful in the treatment of some primary glomerulopathies, vasculitis with renal involvement, severe lupus with kidney disease, and especially in renal transplantation, where it is applied during the

The aged immune system in multiple sclerosis: focus on B cells

Multiple sclerosis (MS) is an autoimmune disorder that affects the brain and spinal cord. A chronic inflammatory reaction causes breakdown of myelin surrounding the axons, leading to a disturbed transmission of nerve impulses. Symptoms of MS include

Lymphocytes T and Treg as prognostic factors of newly diagnosed DLBCL patients

Diffuse large B-cell lymphoma (DLBCL) is an aggressive and most common form of non-Hodgkin lymphoma. The mechanism of DLBCL pathogenesis is not fully understood. Malignant B-cells responsible for lymphoma formation are believed to arise from different stages

Hyper IgM syndrome in North America: a rare disease of a critical step in the immune response pathway

Hyper IgM (HIGM) syndromes are a group of rare genetic disorders leading to ineffective immune responses. People with this immune defect are usually diagnosed in early childhood due to frequent infections. Most of these are common but

Aorta tertiary lymphoid organs: Powerhouses of B cell immunity in atherosclerosis

Cardiovascular disease (CVD) is the leading cause of death worldwide. Yet, our understanding of how the immune system impacts CVD is very limited and immune system-based therapeutic approaches are not in sight. Lymphocytes are major cellular constituents

The thymus: a small organ with a mighty big function

The thymus lies in the chest behind the breastbone and above the heart. Relatively large in infancy, it increases in size until puberty and thereafter shrinks to only a few grams in old age. It consists of