Tag Archives: GTPase

Substrate phosphoswitching: a novel way to regulate enzymatic activity by phosphorylation of its substrate

Schematic diagrams for the GTPase cycle

Cells sense a vast variety of signals by receptors that are distributed on their surface. This perception transduces internal physiological responses using signal pathways, a cascade of protein interacting to bring a change in the cell behavior.

A new strategy against cancer cells. Targeting the Rho-GTPases interactions: The case of the new compound 1A116

For the last decades scientist have been working hard to find cancer´s Achilles heel to design and develop more specific and efficacious therapeutic strategies for cancer. It has become clear that altered cell signaling is a key

Direct regulation of G protein signal strength as a new drug target?

Heterotrimeric GTP-binding proteins (G proteins) remain an important but elusive target in drug discovery. G proteins adapt cell behavior in response to signals generated by cell surface receptors, G protein coupled receptors (GPCRs). Clinical interest in G

Guanine-nucleotide exchange factor that promotes loss of polygonal cell shape

Actin cytoskeleton dynamics determines cell shape and movement. Fibroblasts or epithelial cells, for instance, adhere and spread onto planar surfaces adopting an elongated polygonal shape. Underneath the cytoplasmic membrane, local activation of small GTPase enzymes of the

Phospholipases have a second job, regulating their G proteins

Can we make a weak heart healthy? Can we prevent decline in memory and cognitive ability? The answer may depend on a class of enzymes, phospholipase C (PLC), and their under-investigated ability to directly regulate their specific