Tag Archives: histone
A new class of antisense RNAs that regulate gene expression
Cellular senescence is characterized by a stable cell proliferation arrest in response to different stresses such as oncogene activation. It is thus considered as a major anti-cancer barrier. However, the accumulation of senescent cells can lead to
Muscle wasting with chronic diseases: Can Sirtuins fix the problem?
Prognosis of a chronic disease worsens when associated with uncontrolled muscle loss. Muscle wasting can become the last nail in the coffin when accompanied with chronic diseases like cancer, heart failure, chronic obstructive pulmonary disease and infective
The position of the centromere is marked with ubiquitylation of CENP-A
Chromosomes must segregate equally between daughter cells during cell division, and for proper chromosome segregation, spindle microtubules must attach to a single region of each chromosome, termed the “centromere,” in most eukaryotes. The kinetochore is a complex
A promising compound to be tested against neurodegenerative disorders
Histone deacetylases (HDACs) are enzymes responsible for protein deacetylation. Abnormalities in acetylation levels caused by deregulation of those enzymes are proposed to be involved in the pathogenesis of cancer and neurodegenerative disorders, such as Alzheimer, Parkinson and
