Tag Archives: immunomodulation

Local immunomodulation by Jagged-1 for islet graft acceptance

Type 1 diabetes is a chronic autoimmune disease with a high economic burden worldwide ($327 billion in 2017). Although transplantation of pancreatic islets is a promising approach for treatment of type 1 diabetes mellitus, the engraftment efficiency

The immunomodulatory enzyme IDO: Expression in the uterus of mares?

Detection of IDO protein in the equine endometrium by immunohistochemistry

IDO modulates immune responses. The enzyme indoleamine 2,3-dioxygenase 1 (IDO) degrades tryptophan. This amino acid is required for immune defences against pathogens, but also stimulates pathogen growth. Its degradation inhibits effector lymphocytes and retards pathogen proliferation. Thus,

Features of multipotent mesenchymal stromal cells activation with interferon gamma for clinical use

Multipotent mesenchymal stromal cells (MSCs) are very attractive for cell therapy. For the healing of severe defects in connective tissue (bone, cartilage, fat) their ability to differentiate into various elements of connective tissue origin is used. Their