Tag Archives: membrane proteins

Cryo-electron microscopy in drug development

AoS. Cryo-electron microscopy in drug development

Cryo-electron microscopy (cryo-EM) is becoming the method of choice in structure determination of membrane proteins and has great potential for structure-based drug discovery (SBDD). Cryo-EM provides high-resolution structural information of a membrane protein without the need for

Diving into cell membranes with advanced solid-state NMR methods: harnessing the power of protons

Membrane proteins act as the gateways of the cell. They are essential for the signalling between cells and for the uptake of nutrients; they constitute major drug-targets in human, and their malfunctions are related to severe diseases

Producing cellular transport proteins without cells: a key to study novel molecular targets of malaria parasites

Malaria tropica, the most severe and fatal form of malaria, is caused by mosquito-transmitted, single-celled Plasmodium falciparum parasites. More than 3 billion people in 100 countries live in malaria-endangered areas. Every year, > 200 million new infections

Channels in artificial membranes

Proteins come in a variety of shapes and sizes but two major classes exist: soluble proteins and those reside in membranes. 20-30% of all the proteins found in cells are membrane proteins. Many membrane proteins such as