Tag Archives: mitochondrial

The synthetic cannabinoid XLR-11 and the impaired control of mitochondrial function by the endocannabinoid system as its underlying mechanism of nephrotoxicity

mitochondrial function by the endocannabinoid system

Synthetic cannabinoids (SCs) comprise a diverse group of new psychoactive substances (NPS) designed to activate at least one of the main cannabinoid receptors (i.e. CB1R, CB2R). Variations of SC have rapidly surfaced over the past few years,

Calcium ion by replacing magnesium ion unravels an unexpected role for the mitochondrial F1FO-ATPase

The F1FO-ATPase/synthase is universally known as a complex enzyme machinery which, embedded by the FO portion in the inner mitochondrial membrane and the catalytic F1 sector protruding in the matrix, matches the transmembrane proton flux which occurs

How the mitochondrial F1FO-ATPase can be chemically switched on/off and serve as drug target

The mitochondrial F1FO-ATPase is well known to play the main role in synthesizing most of ATP, thus providing energy to living cells under aerobic conditions. However the enzyme complex can also  work in reverse and split ATP