Tag Archives: neuropathology

Dementia with Lewy bodies and Parkinson’s disease-dementia: Current perspectives

Dementia with Lewy bodies (DLB) and Parkinson’s disease-dementia (PDD) are two closely related major neurocognitive disorders with Lewy bodies of unknown etiology. Both disorders show notable overlap in their clinical presentation, pathological features, biochemistry, and genetic risk

Uncovering mechanisms underlying Parkinson’s disease pathology

Parkinson’s Disease (PD) is a severely debilitating motor disorder characterized by loss of dopaminergic neurons and an increase of α-synuclein in a brain region known as the substantia nigra pars compacta (SNpc). Although much progress has been