Tag Archives: oncogenic
miR-146 and miR-155, two key modulators of the immune response and of the oncogenic transformation
Micro-RNA (miRNAs or miRs) are small noncoding RNAs that negatively regulate protein coding gene transcripts and exert an important role in the control of gene expression. miRs are deregulated in many tumors and play an active role
Oncogenic role of CircPVT1 in head and neck squamous cell carcinoma
Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs that have recently shown to behave as gene regulators in eukaryotic cells, extending our previous knowledge regarding the diversity and complexity of the transcriptome. Nowadays, circRNAs have
p53 gene reactivation reverts hypoxic resistance in KRAS mutant tumor cells decreasing glucose uptake
When growing distant from primary blood supply sites, tumor cells face hypoxia characterized by niches restricted in oxygen and glucose. Cells acquiring resistant to hypoxic stress undergo metabolic re – programming, and increased resistance to 3 –
