Tag Archives: transplantation
Local immunomodulation by Jagged-1 for islet graft acceptance
Type 1 diabetes is a chronic autoimmune disease with a high economic burden worldwide ($327 billion in 2017). Although transplantation of pancreatic islets is a promising approach for treatment of type 1 diabetes mellitus, the engraftment efficiency
Lung “life support”: Enter the era of improving the function of transplanted lungs
Lung transplantation is a relatively new science, with the first successful transplant being performed in 1983 in Toronto, Canada. Almost all transplants performed in this country involve the removal of the lungs from a deceased donor, flushing
Grafting stem cells in 3D arrays
Neural transplantation has continued to show promise as an effective treatment option for neurovascular, traumatic and neurodegenerative disorders. Previous work in neural stem-cell transplantation has demonstrated the ability of distinct neural cells to repair damage and to
Infections erode transplantation tolerance
Organ transplantation is an effective means of treating patients with organ failure, but rejection of the graft remains a major challenge. The life-long use of immunosuppressants needed to prevent rejection makes transplant recipients more susceptible to infections
Melatonin’s role preventing steatohepatitis and improving liver transplantation results
Melatonin (N-acetyl-5-methoxytryptamine) is produced by the pineal gland as well as by many other organs including ovary, testes, bone marrow, gut, placenta, and liver. This molecule is both a biological rhythm regulator and an important component of
Lowering the burden of liver disease in the UK: a blueprint for change
Liver disease is the third biggest cause of premature death in the UK and the number of deaths from liver disease is on the rise (Fig. 1). People can develop liver disease for a number of reasons
Bone marrow transplantation resets the clock in patients with Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia (CLL) accounts for about one third of all of leukemias. In the United States 15,000 patients are diagnosed with and 4,500 patients die of CLL every year. CLL is a diverse disease. Some patients
