Tag Archives: X inactivation

Unlocking a cure from within for X-linked diseases

The mammalian X chromosome is home to many genes that are important for brain development and function, as well as genes associated with reproduction. More than 200 disease-causing mutations have been identified on the X-chromosome. Diseases caused

X chromosome inactivation and escape: skipping Lyon’s law causes sex differences and disease

The sex chromosomes differ between males (XY) and females (XX) in mammals. The present-day sex chromosomes evolved from a pair of look-alike progenitor chromosomes that stopped recombining once sex was determined by a gene on the Y