Tag Archives: compound

The discovery of anticancer compounds as a highly potent and selective Cyclin-Dependent Kinases 4 and 6 inhibitors

2D model of Abemaciclib bound to the active site of CDK6

Cell cycle is a highly regulated process that leads to the transition from quiescence or cytokinesis to cell proliferation through its checkpoints ensures genome stability. More importantly, cyclins and cyclin-dependent kinases (Cdks) play an important role in

Compounded medication for patients with rare diseases

Pharmaceutical compounding is the preparation of unlicensed medicines in order to meet specific patient needs that do not have a licensed (commercial) medicine available on the market. Especially for patients with rare diseases it is complementary when

Design of supplements and nutraceuticals enriched in resveratrol: a promising natural compound

Resveratrol is a polyphenol compound found in grapes, red wine, berry fruits and nuts. Given the favorable prophylactic and therapeutic effects of resveratrol, nanocarriers have been developed for enhancing its bioavailability for further application as supplements or

Protection from DNA-damage with the natural compound resveratrol

Resveratrol is currently known as a health-beneficial natural compound that is contained in grape skins, red wine, and other natural foods. Recent studies suggest that the compound could elongate the life spans of several organisms through a

A transcriptomic approach for cardiac (heart) safety assessment

New drug discovery relies on several phases of safety assessment. One such prominent in vitro safety assessment assay is the “hERG potassium channel assay” for cardiac safety. If a compound blocks the hERG potassium channel in a

From Biomass to Medicines: a cellulose derived product as building block in the synthesis of bioactive compounds

The bio-refinery concept is based on replacing fossil fuel with biomass, having the advantage to use renewable natural raw materials. This topic is currently of interest in academic studies, industrial applications and political strategies, both for the

Design principle of CRY-acting compounds for regulation of the circadian clock

Almost every aspect of our life varies over time: we wake up in the morning, sleep at night, and become hungry at about the same time every day. This is called the circadian rhythm; an approximately 24-hour