Tag Archives: compound
A mass spectrometry view of the interaction of Alzheimer’s disease proteins with an anti-aggregation compound
Alzheimer’s disease is a neurodegenerative disease that has been studied extensively over the last four decades. Millions of people worldwide are affected by this disease, and because our population is growing older, this disease is becoming alarmingly
The discovery of anticancer compounds as a highly potent and selective Cyclin-Dependent Kinases 4 and 6 inhibitors
Cell cycle is a highly regulated process that leads to the transition from quiescence or cytokinesis to cell proliferation through its checkpoints ensures genome stability. More importantly, cyclins and cyclin-dependent kinases (Cdks) play an important role in
Compounded medication for patients with rare diseases
Pharmaceutical compounding is the preparation of unlicensed medicines in order to meet specific patient needs that do not have a licensed (commercial) medicine available on the market. Especially for patients with rare diseases it is complementary when
Design of supplements and nutraceuticals enriched in resveratrol: a promising natural compound
Resveratrol is a polyphenol compound found in grapes, red wine, berry fruits and nuts. Given the favorable prophylactic and therapeutic effects of resveratrol, nanocarriers have been developed for enhancing its bioavailability for further application as supplements or
Protection from DNA-damage with the natural compound resveratrol
Resveratrol is currently known as a health-beneficial natural compound that is contained in grape skins, red wine, and other natural foods. Recent studies suggest that the compound could elongate the life spans of several organisms through a
A transcriptomic approach for cardiac (heart) safety assessment
New drug discovery relies on several phases of safety assessment. One such prominent in vitro safety assessment assay is the “hERG potassium channel assay” for cardiac safety. If a compound blocks the hERG potassium channel in a
From Biomass to Medicines: a cellulose derived product as building block in the synthesis of bioactive compounds
The bio-refinery concept is based on replacing fossil fuel with biomass, having the advantage to use renewable natural raw materials. This topic is currently of interest in academic studies, industrial applications and political strategies, both for the
Design principle of CRY-acting compounds for regulation of the circadian clock
Almost every aspect of our life varies over time: we wake up in the morning, sleep at night, and become hungry at about the same time every day. This is called the circadian rhythm; an approximately 24-hour
