Tag Archives: cystic fibrosis

The use of dry powder mannitol in respiratory disease

The use of dry powder mannitolin respiratory disease

Asthma is an inflammatory disease of the airways causing them to be hyperresponsive to a wide range of stimuli. It is a common disease both in children and adults and most asthmatics suffer from allergies and from

A new drug combination rescues a rare Cystic Fibrosis mutation in patient tissue

University of Toronto researchers in the laboratory of Dr. Christine Bear, together with collaborators at SickKids Hospital (Toronto, Canada) and Proteostasis Therapeutics (Cambridge, Massachusetts), used computer simulations, cell-based systems and patient tissue to interrogate the consequences of

The flipside of cystic fibrosis protein transport

Deficiency of ATP8B1 in humans causes severe progressive liver disease that is characterized by impaired bile flow. Besides liver disease, many ATP8B1 disease patients develop extrahepatic symptoms of yet unknown etiology such as pulmonary infection and defects

Gene therapy: a promising candidate for cystic fibrosis treatment

An improved gene therapy treatment can cure mice with cystic fibrosis (CF). Cell cultures from CF patients, too, respond well to the treatment. Those are the encouraging results of a study presented by the Laboratory for Molecular

Association of polymorphism gene with clinical variability in cystic fibrosis patients

Cystic fibrosis (CF) is an inherited disease, caused by a dysfunction (mutation) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. This disease affects a numerous organs particularly the lungs and digestive system. CF is characterized by

Filamentous bacteriophage organize bacterial biofilms into liquid crystals

At sites of chronic infection, bacteria form biofilms, clusters of bacteria encased within a slimy, polymer-rich coating called the matrix. Biofilms are of concern because bacteria within biofilms become tolerant not only to environmental stresses, but also