Tag Archives: lysosomes
Measuring the pH levels inside lysosomes
The pH level varies in different organelles inside a cell and there is a diversity of function carried out within. Any deviations of pH from normal levels could signal cellular stress or dysfunction and may indicate serious
More than your average bread spread: plant stanols as therapeutical tool in Niemann-Pick type C1 disease
Niemann-Pick type C1 (NPC1) disease is a lysosomal storage disease that affects nearly 1 in 100,000 live births worldwide. NPC1 disease is caused by mutations in the NPC1 gene that result in a dysfunctional NPC1 protein, which
The lysosomal enzyme cathepsin D as novel therapeutic target for non-alcoholic steatohepatitis
The decrease in physical activity combined with increased caloric intake has led us to a global obesity epidemic. Obese patients can develop metabolic syndrome (MetS), which is a term used to assess the risk of a patient
Zooming in on the ‘big eaters’ in atherosclerosis: a key role for oxidation and cellular localization of fat
Our sedentary lifestyle combined with the enrichment of fat in our diet has led to an increase of diseases affecting the health of our cardiovascular system. Cardiovascular disease is one of the leading causes of death, with
Calcium disturbances in Parkinson’s disease
Parkinson’s disease is a common disorder of the brain that affects around 127,000 people in the UK alone. The disease is characterised by the loss of nerve cells (neurons) that control mobility. Symptoms include muscle stiffness, tremor
