Tag Archives: MCF-7
Chromatin architecture changes and replication fork collapse after freezing-thawing
Higher-order chromatin structure (architecture) plays the crucial role in DNA transcription, replication and repair. Defects to DNA architecture are permanently caused by internal cellular processes and various environmental factors, such as exposure to chemicals or ionizing radiation.
The RAS mRNA G-quadruplex: making undruggable cancer targets druggable
In many cancers, RAS proteins are constitutively activated by their oncogenic mutations or activation of their upstream molecules. RAS proteins play a central role in cancer cell malignancy, and drugs that target RAS are therefore believed to