Tag Archives: ribosome

Unraveling multiple checkpoints for accurate selection of initiator tRNA on ribosomes for translation initiation

Ribosomes comprise a large (50S) and a small (30S) subunits. To begin (initiate) protein synthesis, the two subunits associate on an mRNA (70S). Organisms possess two classes of tRNAs, the initiators (i-tRNA) and the elongators. The i-tRNA

A “selfish ribosome” as the origin of cellular life

Could there have been a form of “life” that integrated genetic information, protein translation, and the molecular machinery necessary to replicate itself before the first cells? Might such an entity still exist within our cells as a

Going my way? A tale of enzyme recruitment and activation

Protein synthesis is an energetically costly cellular process, in part due to the metabolic requirements of ribosome assembly and gene-specific messenger RNA (mRNA) production.  Consequently, biosynthetic flux through the protein translation pathway is tightly regulated while translational

Helicase and ribosome share a common mechanism of nucleic acid unwinding

In the cell DNA is present in the duplex form and many messenger RNAs (mRNAs) can form duplex structures. To access the genetic information (represented by nucleotides or codons) on the single-stranded (ss) nucleic acids (NA) by

A potential harmless food bio-preservative — pediocin PA-1

Food safety issues are always around us for food-borne pathogen and spoilage bacteria exist in many kinds of food. Chemical preservatives are added to prevent food spoilage, however, most of them are cancerogen and unsafe for us.