Tag Archives: ROS

NEIL2 repairs DNA damage within active genes, maintains chromosome end integrity, prevents inflammation

Mammalian cells are subjected to a plethora of exogenous and endogenous agents that cause damage to the cellular DNA. One of the major sources of such damage is oxygen-derived molecules and free radicals, collectively termed “Reactive Oxygen

Over-expression of TRX2 reduces p53-mediated cell death in yeast

The p53 gene is a human tumor suppressor which is involved in cell cycle regulation. It has an efficient ability to inhibit cell proliferation, by both blocking cell cycle progression and promoting apoptotic cell death in order

Killing microbes with red light

Photosensitization is a process in which a chemical compound (photosensitizer) that absorbs energy from light is able to transfer that energy to oxygen molecules. As a consequence, reactive oxygen species (ROS), highly toxic to living cells, are

Mitochondrial ROS and cancer drug resistance

The repetitive and continuous circle of resistance to anti-cancer agents was a primary focus of the above-titled articles recently published in Pharmacological Research. Gaining a basic understanding of why so many (possibly all) drugs currently available against

Psychological stress can influence key immune activities and an important protein in the response to infection

The central role played by our immune system is to protect us against infections.  In doing so, the immune response creates a localized toxic inflammatory environment that makes it difficult for the infectious agent to survive.  In

Oxygen affects buds burst in grapevine

Grapevine is the most economically important fruit crop worldwide and is the mainstay of rural communities in over 100 countries. However, grapevine production is concentrated in latitudes of 30°-50°, and largely in maritime regions, due to its

Gene therapy not just counseling for your denim obsession

Imagine a world where one size does not fit all, wait that’s the world we live in now. So why is the treatment you get under the “one size fits all” umbrella, we are all different, right?