Daily Archives: December 7, 2015
Epileptic rats as perfect models to understand epilepsy?
Epilepsy is a neurological disease that affects about 1% of the population in the world, most of them being children and teenagers. Animals suffering from epileptic seizures can also be found in several species (dogs, cats, chicken,
The use of co-crystal technology for stabilizing energetic materials
The use of co-crystallizations is emerging as a new avenue for modifying the solid-state properties of a wide range of high-value chemicals, such as agrochemicals, pharmaceutics, dyes, and nutraceuticals, in such a way that certain physical properties
Posterior cervical fusion may lessen spinal cord compression in patients with rheumatoid arthritis
Patients with rheumatoid arthritis may develop inflammation of the joints in the spine, just as they develop inflammation of joints in their hands, feet, and others. The joint between the first cervical vertebra (C1) and the second
A new role for vitamin D3
Mutations in the genome of body cells (somatic cells) can lead to excess activation of signaling pathways and thus to unlimited cellular proliferation and cancer formation. One such cancer-inducing pathway is the Hedgehog (Hh) signaling cascade, which
Nucleus-targeted anticancer drug delivery
Tumor cell nucleus-targeted delivery of antitumor agents is of great interest in cancer therapy, since the nucleus is one of the most frequent targets of drug action. However, efficient nuclear drug delivery upon systemic administration remains a
New kojic acid-amino acid hybrids as potential tyrosinase inhibitors
Melanogenesis is a process by which melanocytes produce melanin initiated by tyrosinase upon exposure of the skin to UV radiation. Tyrosinase plays an important role in the pathway of melanin biosynthesis from tyrosine. It catalyzes two distinct
Muscling in on molecular machines
The concept of a “power stroke” – a free-energy releasing shape change of a protein – appears in almost every textbook that deals with the molecular details of muscle, bacterial flagella, and many other bio-molecular machines. Researchers
