Tag Archives: brain
Valproic acid treatment for brain tumors
Tumors arising in the brain represent only 2% of all cancers diagnosed in the United States with 23,000 new cases and 14,000 deaths annually. The World Health Organisation (WHO) classifies brain tumors from grade 1 to grade
Innovative tool, promise for treating Alzheimer’s disease and other neurodegenerative brain diseases
If at the dawn of the twentieth century, Alzheimer’s disease was seen as a rare disease, but today the incidence of this disease has taken epidemic proportions and is treated as one of the diseases of civilization.
Global warming: implications for human brain evolution
Climate change is an inherent and complex phenomenon of our planet. Changes in global temperatures can occur directionally in the case of gradual increases or decreases in temperature, and also in terms of greater or lesser variation
We learn and forget to correct our expectations
Learning and forgetting are, to a large extent, about tuning your expectations so that they match your experience. So while it is usually good to learn new things, we sometimes also need to forget things. We constantly
Parkinsonism Hyperpyrexia Syndrome and Deep Brain Stimulation
Deep Brain Stimulation of the subthalamic nuclei (STN-DBS) represents one of the most effective treatments in patients with Parkinson’s disease (PD) with unsatisfactory response to pharmacological therapy. STN-DBS is a neurosurgical approach based on the implantation of
A force behind signal propagation in the brain
Cognitive functions require signal propagation in the brain, i.e., signals propagating via spike trains (at a timescale of milliseconds) in a brain structural network where the nodes and links are individual neurons and synapses, respectively. During a
Personalising meditation with the help of brain research
Therapeutical approach such as meditation (an ancient mind–body practice) that specifically targets stress and associated with it risk factors through regulation of self-related processes may hold potential for lessening the burden of chronic diseases, slowing and possibly
Palpating the brain with MR Elastography to diagnose normal pressure hydrocephalus
Normal pressure hydrocephalus (NPH) is a treatable cause of dementia that accounts for about 6% of dementia cases. It is a condition of elderly individuals of unknown cause, and is characterized by the presence of excessive fluid
Signaling in the brain studied – a role for receptor clustering?
Olfactomedin-1 is a signaling protein in the brain that plays various roles during early brain development. Brain cells (neurons) secrete the protein to the extracellular matrix, where it is known to be involved in several signaling pathways.
Prevention of thromboembolic complications using intermittent pneumatic compression in major brain surgery
Deep venous thrombosis is the most common adverse event after brain surgery ranging from 3 – 26%. We introduced an electric device for the compression of the legs to reduce the risk of thrombosis in the leg
Nitric oxide trigger apoptosis in the brains in Border Disease
Border disease is a pestivirus infection accompanied by central nervous system (CNS) and skeletal abnormalities in sheep and goats. Affected fetuses and newborn animals exhibit brain disorders. This study investigated the relationship between the severity of the
Resting state fMRI analysis using sparse dictionary learning in SPM framework
Brain always be active even people are in rest. In the resting period, it has been observed that particular groups of brain region are always co-activated. These regions are functionally connected each other and each group is
Eye movements: a window to the brain of children with fetal alcohol spectrum disorder
In this paper we examined the accuracy and characteristics of eye movements in children with fetal alcohol spectrum disorder (FASD) and compared these to healthy, typically developing children. FASD may occur when a mother drinks alcohol during
ZNRF1: a key molecule activated by reactive oxygen species to cause neuronal degeneration
Neurons, the major component of our brain, have long processes (called “axons” and “dendrites”) to communicate with other neurons and cells. In many brain diseases that old people get suffered from, such as Alzheimer’s disease, Parkinson’s disease,
Genetically encoded voltage indicators for large scale cortical imaging come of age
Composed of billions of neurons, the brain is the most complex organ that dictates our daily lives. Naturally, understanding the brain is one of the final frontiers that would not only provide basic understanding but also sprout
Stepping to recover from a fall is not helped by Deep Brain Stimulation in people with Parkinson’s disease
Poor balance is common in people with Parkinson’s Disease and can limit the activities people are able to engage in. If a fall occurs the injuries can be debilitating and impair quality of life. The ability to
Small or big, brain cells don’t like protein gunk that lead to diseases like Alzheimer’s, Parkinson’s and Huntington’s
An interdisiciplinary study by scientists at Trinity College Dublin (TCD, Ireland) have answered a hotly debated question in the neurodegenerative diseases research area: “Which protein aggregate form is the primary pathogenic agent in neurodegenerative diseases – (i) the prefibrillar oligomeric
A combination therapy to induce apoptosis in difficult-to-treat cancer cells
The presence of activated PI3K-AKT is a major obstacle to successful chemotherapies. Since PI3K-AKT is activated in many healthy tissues, chemical inhibitors of PI3K-AKT inevitably have many unwanted side effects. By using a cholesterol-targeting drug called beta-cyclodextrin
Albuminuria and cognitive decline
People with type 2 diabetes (T2DM) have a 50-100% increased risk of developing cognitive decline and dementia as compared to people without T2DM. The reasons for this decline are not yet clearly defined but are likely to
