Tag Archives: ER

Regulation of ER Ca2+ homeostasis by disulfide reductase

Intracellular calcium is one of the most important second messengers for the regulation of various cellular processes including protein secretion, muscle contraction, gene transcription, protein degradation and apoptosis. The endoplasmic reticulum (ER) is not only the organelle

A tug-of-war helps shape membranes inside human cells

Imagine if you had to construct an intricate factory consisting of layered platforms interconnected with long tubes, using Lego pieces. The task would become more complex if this assembly would have to be periodically dismantled and rapidly

Calcium disturbances in Parkinson’s disease

Parkinson’s disease is a common disorder of the brain that affects around 127,000 people in the UK alone. The disease is characterised by the loss of nerve cells (neurons) that control mobility. Symptoms include muscle stiffness, tremor

With a little help from friends: how plastids aid the ER to deal with misfolded proteins

Almost a third of all proteins in eukaryotic cells are synthesized and folded in the endoplasmic reticulum (ER) before being secreted and redistributed to other organelles, such as the Golgi apparatus, lysosomes, and the plasma membrane. To