Tag Archives: macrophage

p38α MAP kinase inhibition in atherosclerosis – a new therapeutic tool?

Atherosclerotic cardiovascular disease is the leading cause of mortality worldwide. Selective recruitment of monocytes into the arterial intima and their transformation into macrophage-derived foam cells is one of the earliest events in the pathogenesis of atherosclerosis. Foam

Antimicrobial peptide-loaded hyaluronic acid nanogels as a new strategy for tuberculosis therapeutics

Tuberculosis (TB), a disease caused by the human pathogen Mycobacterium tuberculosis, is one of the most deadly infectious diseases, along with HIV/AIDS. According to the most recent data, 9.6 million new cases of TB were diagnosed worldwide

Modulation of SOCS3 in macrophages can enhance the clearance of dying cells in inflammation

Macrophages, from the Latin meaning “big eaters”, are key cells of the immune system that have the ability to scan tissues in the body and engulf and destroy invading pathogens. They also play a housekeeping role, to

Cultured macrophages help predict lung toxicity of inhaled nanoparticles

Many small particles of industrial or occupational origin are believed to infer an inflammatory or otherwise toxic potential to human health upon inhalation. Knowledge on this issue is especially important for the very small nanoparticles, which measure

Fighting chronic rejection of transplanted organs

In many diseases the only available cure is organ transplantation. However, if the transplanted organ does not derive from an identical twin (which is genetically identical to the recipient) it becomes rejected by the immune system of

Electric fields drive macrophage healing functions

When the skin is cut, or otherwise injured, a spontaneous electrical current is created immediately at the wound and this promotes healing. Several studies have demonstrated how naturally generated electrical fields cause movement of skin epithelial cells,

Topical administration of an antimicrobial peptide as a new strategy for improved burn wound healing

Burn wounds represent a major global concern, as more than 100 million people worldwide are estimated to experience burn injuries every year. These may be caused upon exposure to heat, radiation, chemicals or electric shocks, often resulting