Tag Archives: microfluidics
A combined rapid microfluidics and design-of-experiment approach to optimize liposomal formulations
Nanomedicine has attracted enormous attention for the introduction of advantageous nanoscale materials. Among them, liposomes have devoted considerable concern owing to unique physicochemical and biological properties, as well as the tremendous potential for drug delivery applications. Over
Exploring early mechanotransduction responses
Mechanical stress plays a key role in cellular behaviour and fate, affecting the correct development and functionality of tissues and organs. Due to the complexity of the in vivo cellular environment, most mechanotransduction research relies on the
Simplified molecular diagnostics on a chip for point-of-care diagnostics
Analysis of blood, urine, and saliva often serves as the primary basis of diagnosis and treatment. Clinical specimens contain signature molecules (‘markers’) such as proteins and nucleic acids that are indicators of infection, cancer, and other diseases,
Toward more accessible PET imaging: Miniaturizing the last step of radiotracer preparation
Positron emission tomography (PET) is a 3D body imaging method for visualizing dynamic biochemical processes in living subjects with unparalleled specificity and sensitivity. PET scans, often performed together with CT or MRI imaging, are used clinically to
Design and build your own integrated microfluidic systems using magnetic interconnects
Microfluidic technology involves the miniaturization and integration of complex systems that enable low volumes (microliters, μL; 1 μL = 1×10-6 liter, L) of fluids to be manipulated and controlled in micron-sized (1 micron/micrometer, μm = 0.001 mm)
Microfluidic tumor models help pre-clinical screening of T cell cancer immunotherapies
Cancer immunotherapy draws upon the patient’s own immune system to recognize and fight the disease. One form of cancer immunotherapy is known as adoptive T cell therapy (ACT) consisting of isolation, genetic manipulation and reinfusion into the
Centrifugal capillary-based microfluidic methods for synthesis of artificial cell-like systems
For decades, researchers have attempted to construct artificial cell – like systems using biomolecules such as DNA, RNA, proteins, and lipids. Artificial cell – like systems are microcapsules constructed from giant liposomes or water-in-oil (W/O) microdroplets that
Sphere remains sphere! Moving droplets by electric fields
Liquid bridges play an important role in our everyday life. On the beach we benefit from their stability when we build sand castles, while in some other situations liquid bridges can be annoying, for instance when they
Microfluidic live-cell microarrays
In recent years, the development of new drugs and therapies has decelerated despite the application of combinatorial biochemistry and new therapeutic strategies, such as nanoparticle-based drug delivery systems. Although the numbers of newly developed compounds have steadily
A complete molecular diagnostic test on a compact disc
A challenge in health diagnosis today involves the rapid analysis of genomic information in tests called molecular diagnostic assays. These tests can analyze a person’s bodily fluids to determine the cause of sickness, and can detect a
