Tag Archives: microglia
Extracellular cytochrome c: a novel damage-associated molecular pattern (DAMP) of the brain
Cytochrome c (CytC) is a protein that is normally located inside mitochondria where it participates in the energy-generating processes of cells. Since mitochondria are essential for life, these CytC-containing organelles are found in most animal cells. The
Biomarkers for Alzheimer’s disease diagnosis: an eye on retinal inflammation
Alzheimer’s disease is one of the most common neurodegenerative disorders. Alzheimer’s disease cases are constantly increasing worldwide due to population aging. Typical symptoms of the disease include memory loss, cognitive deficits, personality and behavior modifications. At the
The voltage-gated potassium channel, Kv1.3, at the crossroads of glial functions in glioma
Glioblastoma multiforme (GBM) is one of the most lethal cancers in adult humans, with a frequency of 6:100.000 people. Despite the current three-modality therapy, which includes surgery, radiation and chemotherapy, the clinical outcome of GBM patients remains
Incretin hormones and brain microglia team up to regulate brain homeostasis
The entire human body is made up of many complicated cells, processes, and interactions. As scientific discoveries are made, it becomes increasingly more evident how multidimensional and interconnected all of the biological systems and pathways of the
Acute immune responses in the brain differ from responses in blood
Immune cells of the brain called microglia, appear to have been adapted to their vulnerable environment. They react less destructive to danger signals than their counterparts in the blood. Microglia are the resident macrophages of the central
CSF-1 receptor and its activators – new players in the nervous system and neurological disease
Macrophages, meaning big eater (from the Greek, makros (large) and phagein (to eat)), are cells, present in all tissues of the body, that engulf and degrade large foreign particles, such as microbes and also scavenge abnormal self
Can metal-exposure induce innate immune reactivity in brain cells and thus contribute to neurotoxicity?
Use of metals in dentistry is quite common for braces, crowns, fillings, implants. Problems sometimes occur, such as allergy, locally inflamed mucosae, or vague symptoms throughout the entire body. However, alternatives such as methacrylates will never completely
