Tag Archives: TP53
Wilms tumor and aneuploidy
Wilms’ tumor or nephroblastoma is an embryological tumor of infancy that belongs to the category of “small round blue cell tumors” (Fig. 1). Such tumors are characterized by an accentuated basophilia of the nuclei with a notable
Oncogenic role of CircPVT1 in head and neck squamous cell carcinoma
Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs that have recently shown to behave as gene regulators in eukaryotic cells, extending our previous knowledge regarding the diversity and complexity of the transcriptome. Nowadays, circRNAs have
Mutant TP53 disrupts age-related accumulation patterns of somatic mutations in multiple cancer types
Most cancers are driven by somatic mutations in proto-oncogenes and tumor suppressor genes. Genetic changes in a tumor may accumulate in the tissue self-renewal phase prior to neoplasm. The risk of sporadic mutations increases with age. In
Protection from DNA-damage with the natural compound resveratrol
Resveratrol is currently known as a health-beneficial natural compound that is contained in grape skins, red wine, and other natural foods. Recent studies suggest that the compound could elongate the life spans of several organisms through a
