Tag Archives: transcription

LMO1 regulates a novel oncogenic pathway druggable for neuroblastoma

LMO1 regulates a novel oncogenic pathway druggable for neuroblastoma

Neuroblastoma (NB) is derived from neural crest cells and its main developing sites are adrenal gland and sympathetic ganglions. It is the most common extracranial solid tumor in childhood, accounting for more than 7% of malignancies in

Transcription factor information system: A tool for detection of transcription factor binding sites

Transcription Factors are proteins those bind to DNA at specific sites (Transcription Factor Binding Sites or TFBSs) and control the gene expression. Hence identifying these TFBSs in DNA is important to understand the mechanism that regulates gene

G-quadruplexes: novel DNA structures controlling life from the beginning

The process by which a single cell, the zygote, becomes a fully formed organism has been a historic scientific enigma. Now we know that the information stored in the genes of the DNA is the responsible for

How actinomycin binds to DNA and exerts its mechanism of action

In this remarkably simple and profound article — recently appearing in the March issue of the Journal of Structural and Functional Genomics — Henry M. Sobell describes his theory for the existence of “premeltons” in DNA —

Can the developmental synchrony be affected by the mothers?

Biological synchrony is a ubiquitous yet highly diverse phenomenon, with examples as wide-ranging as applause among humans, migration of fish and birds, aggregation of insects, and mass flowering of bamboos. Developmental synchrony, resulting from reduced fluctuation in

Control of cell identity by the nuclear architecture

In a complex organism, all cells use their identical genetic potential to differentiate into a variety of cell types characterized by different morphology, nuclear shape and function. This is possible because only a small subset of genes

A factor that regulates the expression of HIV genes

Proteins are the machinery of life. Nearly everything in a cell is manufactured by, regulated by or composed of proteins, which are encoded in genes. When a cell needs a particular protein, the DNA encoding the protein

The hierarchy of transcriptional activation: from enhancer to promoter

Disturbance of gene expression underlies many diseases. Deciphering how genes are normally switched on and off in healthy cells during development and cell differentiation is helping to shed light on the molecular basis of diseases such as

A variant RNA polymerase controls bacterial pathogenicity and stress responses

In order for cells to carry out normal functions, the genetic information stored in DNA needs to be first converted to RNA. This conversion – known as transcription – is carried out by a class of enzymes