Monthly Archives: December 2020
Cryo-electron microscopy in drug development
Cryo-electron microscopy (cryo-EM) is becoming the method of choice in structure determination of membrane proteins and has great potential for structure-based drug discovery (SBDD). Cryo-EM provides high-resolution structural information of a membrane protein without the need for
TMEM165; The Bermuda triangle of glycosylation and Golgi Mn homeostasis
During evolution, eukaryotic cells have acquired a complex network of endomembranes delimiting distinct organelles with specific cellular functions. In mammals, the rough endoplasmic reticulum (ER) and the Golgi apparatus are two key organelles of the secretory pathway
Strong primary healthcare may reduce mortality
Healthcare is variably organized across the world. In some places, people attend medical specialists such as cardiologists and urologists directly. In other places, people attend primary care physicians for most health problems and, if necessary, they refer
Global climate change and mental health
In the past decade, several empirical studies and systematic reviews of the literature have documented the mental health impacts of global climate change. However, the range of impacts and their relationship to specific forms of climate change
Atmospheric and genetic parameters influence Rhinovirus transmission
Rhinoviruses are a diverse set of very small and common viruses, repeatedly infecting humans in the course of a single year. For most people, infection usually results in mild common cold symptoms, and spontaneously resolves without the
Botulinum toxin and occupational therapy for Writer’s Cramp
Dystonia is a neurological disorder characterized by abnormal postures that interfere with making movements. Writer’s cramp is the most common type of dystonia involving the upper extremity. Patients initially experience painless loss of control while writing, discomfort
Can SEM/EDX analysis be useful in prosecution of medical malpractice?
Forgetting surgical gauzes within a patient’s body after surgery is a serious matter but also sadly known to the newspapers. The retained gauzes may cause severe inflammatory reactions and numerous complications up to death; exceptionally, they can
