Monthly Archives: November 2020
Targeted GRP78 pathway for improved vision in diabetic retinopathy
Diabetic retinopathy, is a complication of diabetes which causes vision loss and eventual blindness in adults. People with diabetes have more sugar in their blood than normal, which causes their bodies not to function correctly. Often proteins
A method for highly sensitive detection of D-amino acids
D-amino acids have recently attracted much attention in various research fields including medical, cliDical and food industry due to their important biological functions that differ from l-amino acid; thus, there has been an increasing need to develop
Nickel free, built-in nanotubular drug eluting stents
Coronary Artery Disease is a common cause of heart failure. Coronary Artery Disease (CAD) is caused by the accumulation of lipids and fats within an injured arteries’ walls and restricts the blood flow to the heart muscle
The suitability of scopolamine as an Alzheimer’s model
Alzheimer’s disease is the most common cause of dementia. About 50 million people worldwide have Alzheimer’s disease or a related form of dementia. Alzheimer’s disease is a terminal illness affecting mostly the elderly above the age of
Imaging metal nanoparticle adsorption on graphene aerogels
The functionalization of porous carbon aerogels and sponge-like materials with metal nanoparticles (NPs) has shown significant promise for several applications, including energy storage and harvesting and environmental remediation. Methods for imaging the internal structure of these porous
Impact of temperature on physicochemical and biological properties of silver-silica nanocomposite
The future of a well-known consumer world seems to be closely related to multifunctional engineering nanomaterials fulfilling a completely new role comparing them with the traditional structures and products. Such materials are inclined to sophisticated applications e.g.
Serum cytokine profile in mice after injection of supernatants of group A streptococci culture
Cytokines are involved in various pathophysiological processes of macroorganism, including regulation of immune response and inflammation. Numerous experiments have demonstrated that cytokines, necessary in small doses, may result in the development of “cytokine storm” when produced in
How mitochondria “sense” and respond to changes in oxygen concentration in vivo
Mitochondria – intracellular organelles – are our organism’s “powerhouse”, the main oxygen sensors that play the signaling role as modulators of oxygen consumption and regulators of the rate of oxygen delivery from the extracellular environment. Changes in
How can we measure problematic videogame use among adolescents?
Playing video games is currently one of the most frequent leisure activities in young people and adolescents, but it generates a social alarm because it is associated with negative consequences such as family or scholar problems, reduction
Strengthening the Paris Agreement by supply-side climate policies
To reach the Paris Agreement’s goal of keeping global warming well below 2 degrees, much of the world’s deposits of oil, gas and coal must be left permanently in the ground. In an article published in Science
Why photobiomodulation therapy is helpful for diabetic wound healing? Fibroblast answers!
It is an obvious well-known issue that diabetic wounds are poorly healing, but the molecular and cellular alterations leading to this impairment is not clear. Many studies concluded the dysfunction of dermal fibroblasts as the main responsible
Modulating the distribution and fate of MSCs following therapeutic delivery may enhance their efficacy
Mesenchymal stem/stromal cells (MSCs) can be isolated from multiple adult tissues and have been shown to produce factors which can protect cells from diverse injurious stimuli, favourably modulate the immune response, and enhance tissue reparative and regenerative
The roles of mesenchymal stem cells secretome in diabetic wound healing
There has been a fourfold rise in the number of diabetics from 108 million in 1980 to 422 million in 2014 and by 2040 the number will reach to 642 million. Diabetes mellitus drastically influences normal functioning
Upstream open reading frames (uORFs) as translational regulators in human disease
The messenger RNA (mRNA) translation process is a key step of gene expression, whose regulation allows the cell to rapidly change protein synthesis in a spatio-temporal manner in response to different stimuli. Translation comprises four steps –
Medical grade honey facilitates the healing of minor injuries in pediatrics
Children are at risk to injuries and wounds as it is their nature to play and explore in adventurous environments. At the same time, they are less experienced in calculating the risk when performing some stunts. However,
Electronic liquid crystal: A key ingredient for solving a long-standing mystery of the high-temperature superconductivity
The phases of matter are characterized by the symmetries inherent to each state. Imagine the freezing from water to ice. This phase transition is accompanied by the crystallization of H2O molecules, forming a periodic structure in a lattice.
Investigating SOCS3 as a new target for drugs to treat pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a fatal disease caused by the walls of the small blood vessels that supply the lungs walls becoming thicker (Fig. 1) and unable to adapt to changes in blood flow, resulting in
The quest for smart radio frequency materials
Reconfigurable and tuneable wireless devices are the ultimate goal of all generations of wireless technologies – starting from the first generation all the way to the current, fifth generation. And the interest is ever growing. It is
Extracellular cytochrome c: a novel damage-associated molecular pattern (DAMP) of the brain
Cytochrome c (CytC) is a protein that is normally located inside mitochondria where it participates in the energy-generating processes of cells. Since mitochondria are essential for life, these CytC-containing organelles are found in most animal cells. The
Interesting structural properties of auricin and its biosynthetic gene cluster
Streptomycetes belong to the main producers of secondary metabolites with a broad range of biological activities. A large number of these products belong to polyketides. These structurally diverse compounds are synthesized by a repeated decarboxylative condensation from
