Tag Archives: gene

G protein signaling: a major culprit of essential hypertension

Blood pressure (BP) is the driving force that distributes the blood to the organs of the body according to their instantanous needs. It may be increased by pressor agents acting on the heart, vessels, and blood volume,

Gene therapy: a promising candidate for cystic fibrosis treatment

An improved gene therapy treatment can cure mice with cystic fibrosis (CF). Cell cultures from CF patients, too, respond well to the treatment. Those are the encouraging results of a study presented by the Laboratory for Molecular

Genome sequence of the natural antagonist Pseudomonas fluorescens 2-79 against fungal plant diseases

In agriculture we have to deal with a huge variety of diseases caused by phytopathogenic bacteria, fungi or insects for instance. Many of these plant pathogens live in the soil and attack the respective cultivar at the

Why do people undergo genetic testing – for personal benefits, for family, or for science and society?

Genetic testing is an important tool to detect gene mutations (e.g., BRCA1/2) that increase the risk of cancer, especially among those who are known to have higher chances of carrying these mutations such as Ashkenazi Jewish individuals.

Prader-Willi syndrome: most common genetic cause of life-threatening obesity

Prader-Willi syndrome (PWS) is a rare complex multisystem genetic disorder. It is recognized as the most common known genetic cause of obesity in humans which can be life-threatening, if not controlled. PWS affects about 1 in 15,000

Association of polymorphism gene with clinical variability in cystic fibrosis patients

Cystic fibrosis (CF) is an inherited disease, caused by a dysfunction (mutation) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. This disease affects a numerous organs particularly the lungs and digestive system. CF is characterized by

Whole-cell computational models can predict how genes influence behavior

Since the early 1900’s, scientists have known that cells are composed of multiple components, including small molecules, DNA, RNA, and protein. Over the past fifty years, scientists have systematically measured these individual components and their interactions. Despite

Genes are read backwards to restructure our DNA

In English, we read in one direction – from left to right across the page. We need to read words in a certain order, so that the information makes sense to us. In the cells of our

How to know transcription factors by the company they keep

The ENCODE project is a massive data-collection effort set out to understand the function of the human genome. The collection comprises many types of genomic data, including the localization of transcription factors onto DNA. Transcription factors are

A resource for studying the role of RNA-binding proteins in human disease

Advances in science and technology have not only made accessing and analyzing the personal genomic information a reality but also rapid and cost effective. Every living organism is made of cells and every cell is made of

Escherichia coli K-12 as a model to understand gene regulation

Escherichia coli K-12, a bacterium of the normal flora of humans, represents one of the most important model organisms in biology. This microorganism has been completely sequenced at DNA level, and contains 4319 genes. An important element

Controlling gene expression in bacteria

Gene expression enables cells to implement the instructions encoded within the genes on their DNA. Being able to control gene expression is therefore key to this most fundamental biological process, so determining cell fate and behaviour. Cells

From milliseconds to lifetimes: dynamic behavior of transcription factors in gene networks

When living organisms are exposed to a sudden change in the environment, many genes are turned on in an organized manner to enable the organism to cope and respond to the changing environment. This coordinated genome-wide response

The genesis of plant languages: How plants evolve new metabolic pathways from existing ones

There are an estimated 100 million species on this planet, with a stunning array of shapes, sizes, physiologies and behavior. One question that has excited evolutionary biologists since Darwin is – how does all of this biological

Public attitudes to GM food

Public concern can often be a stumbling block to successful innovation, particularly when the underlying science breaks new ground. This does not just affect peoples’ readiness to consume new products, but may also affect the regulatory environment.

A genetic switch for your health

We all have heard that reducing your caloric intake improves your health and may even extend your life. A fascinating aspect of calorie restriction is that it has similar beneficial effects in virtually all animal species tested.

Differentiation of pathogenic races of the lentil anthracnose pathogen C.lentis using effectors

The genus Colletotrichum has been under revision for the last decade. It contains species of high economic importance as pathogens of major crops, but also includes species that are model organisms to study host-pathogen interactions. The hemibiotroph

Mutations in the gene DLL4 cause Adams-Oliver syndrome

Adams-Oliver syndrome (AOS) is a rare hereditary disorder that occurs in 1 in 225.000 individuals and is characterized by the presence of both scalp and limb defects. Congenital anomalies of the heart and blood vessels are also

AMPK: Common mechanism of action linking HIV-1 latency and Hutchinson-Gilford progeria syndrome

Although any connection between HIV-1, the virus that causes AIDS, and Hutchinson-Gilford progeria syndrome, a rare genetic disorder that exhibits symptoms of accelerated aging in children, would appear unlikely, splicing of the latent ( i. e. dormant)

Too much or too little of one gene, CHRNA7, is associated with many neuropsychiatric disorders

In the human genome, certain regions are unstable and are found to have missing ( deletions ) or extra ( duplications ) pieces of chromosome. Many of these deletions and duplications have been implicated in neurological disease,