Tag Archives: insulin resistance
Excessive postprandial VLDL remnants in plasma cause obesity and insulin resistance
Remnant lipoproteins (RLP) are the TG-rich lipoproteins metabolized by lipoprotein lipase (LPL) and increase in plasma after fat intake (Fig. 1), parallel with the increase of plasma triglycerides (TG). We have long thought that RLP in plasma
Metformin and stem cells act synergistically to treat insulin resistance
One of the principle defects of type 2 diabetes is insulin resistance which is the inability of insulin to exert a biological action at the level of its target tissue viz. muscle, fat and liver. Metformin is
Type I interferons fuel adipose inflammation in obesity
When people get fat the visceral adipose tissue (VAT), fatty deposits inside the body that cling around the internal organs, get inflamed. This chronic low grade inflammation is termed metaflammation. Metaflammation has been found to contribute to
Insulin effects on pancreatic beta cells-not always what you may think
Normally, blood glucose levels are controlled within a reasonable range by the release of insulin from pancreatic beta cells in response to an increase in blood glucose levels following a meal or other glucose challenge. One of
Low salt intake during pregnancy
All cells of an organism share the same DNA sequence from the time they are stem cells until they are fully differentiated, differing greatly in relation to the profile of expressed genes. Changes in gene expression which
The vicious cycle in liver that fuels the obesity diabetes pandemic
Experimental obesity is readily produced by dietary excesses of fats or carbohydrates and involves an initial increase in glucose production by the liver with subsequent increases in blood insulin levels, i.e., an insulin-resistant state. In turn, elevated
