Tag Archives: p53
Cardiomyocyte Metabolism Research and Cardiogen Peptide
Peptide complex Cardiogen has been hypothesized to function as a bioregulator of cardiovascular function. Fibroblasts, the cells often credited with scar formation and tissue regeneration, are proposed to be the principal targets of Cardiogen in investigations. H-Ala-Glu-Asp-Arg-OH
Oncogenic role of CircPVT1 in head and neck squamous cell carcinoma
Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs that have recently shown to behave as gene regulators in eukaryotic cells, extending our previous knowledge regarding the diversity and complexity of the transcriptome. Nowadays, circRNAs have
p53: key conductor of all anti-acne therapies
Acne vulgaris is the most common inflammatory skin disease of developed countries affecting more than 80% of adolescents. In contrast, acne vulgaris is not epidemic or completely absent in populations living under Paleolithic conditions. During the last
p53 gene reactivation reverts hypoxic resistance in KRAS mutant tumor cells decreasing glucose uptake
When growing distant from primary blood supply sites, tumor cells face hypoxia characterized by niches restricted in oxygen and glucose. Cells acquiring resistant to hypoxic stress undergo metabolic re – programming, and increased resistance to 3 –
Chronic lymphocytic leukemia (CLL) diagnostics better to do in cultivated than native cells
Cancer is an age associated disease. In Western countries with people having longer life expectancies than e.g. 100 years ago, this means at present that 1-2% of those individuals are confronted with the diagnosis of leukemia during
Is chromatin remodeling required to modulate embryonic development?
Chromatin remodeling is active critical process during embryonic development and in cellular malignancies such as cancer. Chromatin is the highly condensed form by which the genomic material (DNA) is packaged in the cell nucleus. The fundamental subunit
Genes on or off! How regulatory DNA variations disrupt the balance of P53 and cMYC binding
Identification of causative DNA variants in common complex diseases is very important to screen individuals with high-risk for diseases and for developing therapies to target the genetic cause of diseases, in particular cancer. DNA variations that lie
Over-expression of TRX2 reduces p53-mediated cell death in yeast
The p53 gene is a human tumor suppressor which is involved in cell cycle regulation. It has an efficient ability to inhibit cell proliferation, by both blocking cell cycle progression and promoting apoptotic cell death in order
