Tag Archives: transcription factors
Sheath blight of rice: challenges and management
Rice (Oryza sativa L) is one of the most widely consumed cereal crops, grown in more than a hundred countries. Around 40,000 different varieties of rice exist in the world, with China producing the largest amount of
Visualizing transcription factor dynamics, one molecule at a time
In a multicellular organism, each cell type expresses only a subset of genes encoded in the genome. Moreover, hundreds of genes can be regulated by external stimuli. This complex regulation is mediated by proteins called transcription factors.
Recurrent ontogenesis
Flowering plants arose during the Cretaceous, and up to date they count around 235,000 species, representing the largest and most diverse group within the plant kingdom. One of the foundation of their success relies upon the production
Molecular players behind sunflower architecture: differential transcription of two genes
During plant embryogenesis the primary axis of development is established by two groups of pluripotent cells: the shoot apical meristem ( SAM ), responsible for aboveground organs generation, and the root apical meristem (RAM), responsible for underground
The evolutionarily conserved role of Sp1 in appendage morphogenesis
Despite millions of years of independent evolution, some aspects of vertebrate and arthropod development share striking similarities. For example the appendages of a mouse and of a fly, at the naked eye doesn’t seem to share too
Molecular cardiology: refocusing on diastolic (dys)function
The pumping of the heart consists of alternate contractions (systole) and relaxations (diastole). The inability of the left ventricle (LV) to eject (systolic dysfunction) or fill (diastolic dysfunction) blood most frequently leads to heart failure (HF) with
Genes on or off! How regulatory DNA variations disrupt the balance of P53 and cMYC binding
Identification of causative DNA variants in common complex diseases is very important to screen individuals with high-risk for diseases and for developing therapies to target the genetic cause of diseases, in particular cancer. DNA variations that lie
ATF3-dependent cross-talk between cardiomyocytes and macrophages promotes cardiac maladaptive remodeling
Cardiovascular diseases are disorders of the heart and blood vessels which are leading to heart failure. Cardiovascular diseases correspond to 30% of all deaths in the world. The molecular processes that undergone from a healthy heart to
Escherichia coli K-12 as a model to understand gene regulation
Escherichia coli K-12, a bacterium of the normal flora of humans, represents one of the most important model organisms in biology. This microorganism has been completely sequenced at DNA level, and contains 4319 genes. An important element
From milliseconds to lifetimes: dynamic behavior of transcription factors in gene networks
When living organisms are exposed to a sudden change in the environment, many genes are turned on in an organized manner to enable the organism to cope and respond to the changing environment. This coordinated genome-wide response
