Monthly Archives: February 2017
The promiscuous mineralocorticoid receptor
Hormones and nerves are the key communication systems in the human body. Nerves are like a fixed-line telephone network, capable of very fast messaging: think of the pianist’s fingers playing the Minute Waltz. Hormones are like radio,
Drugs from the sea: complex structures to fight a complex problem of resistance in cancer
It is well known that incidence of cancer cases figures among the leading causes of morbidity and mortality. Most of disseminated cancers share the common feature of not responding to anticancer drugs. This phenomenon is known as
Algae and moulds: Causative agents of respiratory tract disease in horses?
This investigation identifies the alga Prototheca and the mould Pithomyces chartarum as rare causes of upper respiratory tract inflammation in horses. More frequently, upper respiratory tract disease in horses is caused by viral and bacterial infections. Patients:
Microneedle patch for fast and sustained pain relief
The occurrence of pain is very common in routine life and during invasive clinical procedures, such as injections, surgeries etc. which is the usually treated using painkiller and local anesthetics in form of oral dosage forms, creams,
Lung cancer imaging before surgery and the role of brain MRI
Lung cancer kills more people each year than any other cancer worldwide. The best chance at curing the cancer is with surgery, however not all lung cancers can be taken out. Surgeons use a variety of imaging
Atelocollagen-conjugated miR-520d-5p is effective dramatically in therapy-resistant undifferentiated cancers
We have previously shown that hsa-miR-520d-5p can convert cancer cells into induced pluripotent stem cells (iPSCs) or mesenchymal stem cells (MSCs) via the demethylation and consequent upregulation of TP53 in vivo. We have also reported that miR-520d-5p
Mechanism of the tumor suppressive properties of glycodelin
Malignant growth in cancer is characterized by loss of cell differentiation, uncontrolled proliferation and resistance to apoptosis. In some cases it is possible to revert malignant cells back to normal. However, this process is not very well
Lipid modified natural RNA
tRNA is an integral part of the protein translation process. It translates the genetic code from mRNA to make the corresponding protein. The process of protein translation requires a well-defined structure of specific tRNA and its ability
The Fracture Liaison Service. A standardized order set towards efficient management of fragility fractures with minor expenses
Over more than a decade, the secondary fracture prevention strategy has been the heart of osteoporosis-related fracture management studies. Management programs have oscillated between low and high levels of intensity of intervention(s); sensitization through letters or pamphlets,
Stopping the spread of diarrheal disease through the environment
More than half a million children die every year from diarrheal diseases. Most of these diseases are caused by pathogens, or “germs”. In my paper Environmental Transmission of Diarrheal Pathogens in Low and Middle Income Countries published
Small dense LDL, sub-clinical atherosclerosis and psoriatic arthritis
Psoriatic arthritis (PsA) is a chronic arthropathy associated with psoriasis, marked by an axial and/or peripheral joint involvement and high cardiovascular. Several large studies confirmed the relationship of small dense LDL (sd-LDL) with coronary events. Although some
Acute stroke in 3 brain territories suggests cancer
Over the past several decades cancer has increased to rival heart disease as the leading cause of death in the United States. Non-infectious endocarditis and cancer-associated hypercoagulation (C-AH) have both been suggested as a source of stroke
Artemisia annua leaves improved solubility of antimalarial drug, artemisinin
Artemisia annua L., also known as Sweet Annie, is a Chinese medicinal herb that produces the important antimalarial drug, artemisinin. Artemisinin is the most powerful antimalarial ever discovered and its derivatives are the main component of artemisinin
How can we observe the evolution of the species: an example of the New Zealand damselfly genus Xanthocnemis?
This article is part of a large research that investigates the taxonomy of the endemic to New Zealand damselfly genus Xanthocnemis. Prior to the beginning of this study, four species have been reported for the genus: X.
Steroid hormones regulated the cellular immune response of the crustacean
The endocrine system plays a crucial role in metabolism. Endocrine – secreted materials regulate the growth , development, reproduction, and immune response of organisms. In crustaceans , steroid hormones have been synthesized by feeding cholesterol as the
Gut microbiota: A potential trigger of rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder characterized by synovitis in multiple joints and systemic comorbidities. Both genetic and environmental agents are thought to be the risk factors for arthritis. Recent studies have suggested that
Transgenic high-lysine rice may offer a truthful solution to malnutrition?
Amino acids are among the most important components in living organisms being the backbones of proteins that are critical to the survival of all living organisms, including plants. Unfortunately human beings and most of their farm animals
Genetic modification for crop improvement
Genetic modification (GM) of crops involves the transfer of genes for specific traits between distantly related plant species using recombinant DNA technology known as transgenesis. Besides, crops can also be modified by silencing or overexpressing its endogenous
Is it possible to operate multiple times endoscopically a person with incisional hernia?
An Incisional Hernia is a hernia that occurs through a previously made incision in the abdominal wall, in the scar left from a previous surgical operation. The first time that an incisional hernia was treated with minimally invasive
Effect of tenapanor on sodium absorption and interdialytic weight gain in patients with advanced kidney disease
The major function of the kidneys is to eliminate waste products and excess fluid from the body, through the production of urine. Patients with kidney failure need dialysis, typically three sessions per week, as an artificial replacement
