Daily Archives: October 25, 2018

Emerging diversity of the CRISPR-Cas system in cholera phages

Interactions of bacteria and their phages, which are viruses hostile to bacterial survival lead to the evolution of numerous phage resistance mechanisms.  CRISPR-Cas (clustered regularly interspersed short palindromic repeats-CRISPR-associated proteins) is such a defense system of bacteria. The

Organic synthesis provides 17,18-EpETE and isoleukotoxin diol in optically active forms

The epoxide ring opening of the trimethylsilyl substituted epoxy alcohol 1 (R1 = H) by CH3S(O)CH2Na (NaDMSO) produces anion 2 as the transient species, which undergoes an unusual reaction rather than the Peterson olefination (Fig. 1). When