Tag Archives: cancer
The protein p62 helps liver cancer-initiating cells survive
The most common form of adult liver cancer is hepatocellular carcinoma (HCC), which is the third-leading cause of cancer deaths worldwide. HCC arises from persistent liver inflammation related to hepatitis B or C infection, alcohol consumption, or
Cancer can growth without angiogenesis. A new field opened in cancer biology
The word cancer derives from the Greek “karkinos “which means “crab”. According to the legend reported by Paul of Aegina in the 7th Century AD, this name was chosen because this disease “has the veins stretched on
STAT3: The double edged molecular sword in Chronic Lymphocytic Leukemia cells
The common denominator of different types of cancers is an ever expanding clone that originates from a single cell. In acute leukemia the clonal expansion may be very rapid and the clone double its size sometimes within
Loss of Trpm2 does not potentiate standard acute myeloid leukemia chemotherapy
Leukemia is a cancer of the blood that affects thousands of people of all ages (including children and even babies). Treatment is very toxic, and often fails to cure patients. Leukemia is caused by mutations in specific
Novel Cancer Therapeutics Summit 2016
Organizer: GTCbio Start date: November 7th, 2016 End date: November 9th, 2016 We invite you to attend the 2016 Novel Cancer Therapeutics Summit, to be held on November 7-9, 2016 in San Francisco, CA. This summit includes
MTA3: A master coregulator of physiology and oncogenesis
The discovery of novel therapeutics for treatment of cancer is today’s prime concern due to abundantly increasing cancer drug resistance and deaths worldwide. MTA3, a member of metastasis-associated protein (MTA) family, plays unique and collaborative roles in
Why is radiation treatment more effective for cancers caused by HPV?
Human papilloma virus (HPV) is the most common sexually transmitted infection in the United States and can lead to cancers in the affected organ such as the cervix. In the last 15 years, the rise in prevalence
Surprisingly diverse impacts of SMARCB1 loss on gene expression programs in a lethal pediatric cancer
Malignant rhabdoid tumors (MRTs) are aggressive childhood cancers that are often resistant to chemotherapies and spread to other areas in the body (metastasis), making them one of the most lethal solid cancers known. Primary MRTs are frequently
Is the best cancer offense a good defense?
Although the unique DiRas (Distinct subgroup of the Ras family) family of small GTPases shares homology with the pro-oncogenic Ras GTPases, it has tumor-suppressive actions. DiRas1 (also known as Di-Ras1 or Rig) has been reported to be
Long learning curve for surgeons operating on esophageal cancer
Esophageal cancer is the eighth most frequently diagnosed cancer worldwide and the sixth most common cause of cancer-related death. The curatively intended treatment usually includes extensive surgery with removal of most of the esophagus (food-pipe) and the
Who is a cancer survivor? A brief overview of this controversial term
Chiara Marzorati, Foundations of the Life Sciences Bioethics and Cognitive Sciences, European School of Molecular Medicine (SEMM), European Institute of Oncology, Via Adamello 16, 20139, Milan, Italy. Gabriella Pravettoni, Department of Oncology and Hemato-oncology, University of Milan,
CCN proteins : A new vista for molecular medicine
The CCN family of proteins is composed of six members playing critical biological roles, both in normal and pathological conditions. The first three CCN proteins discovered were designated Cyr61, Ctgf, and Nov because of the context in
Improving cancer care: Counseling patients on quitting smoking
Given the damaging effects of continued smoking on cancer management and post-treatment survival, all oncology practitioners should provide brief counseling to patients who smoke, encouraging them to quit smoking and referring them to specialized care (i.e. tobacco
Orphans and inflammation
Many are now well-aware of the negative impact of inflammation on our health, including cancer as well as rheumatologic, metabolic and neurologic disorders. Insults to the body either through injury (acute or chronic), or poor diet can
Why women with early stage breast cancer don’t complete their chemotherapy treatment?
Breast cancer is a leading cause of cancer death among US women. For women with early stage breast cancer (stages I and II), completing chemotherapy after surgery can increase survival. Despite this proven benefit, some women do
African American, Latino, and older patients in a Comprehensive Cancer Center
The National Cancer Institute (NCI) is considered the leader in cancer research in the United States. The NCI recognizes 68 healthcare facilities as centers of excellence in cancer research and treatment. Of these, 41 are designated Comprehensive
Novel approaches to cancer treatment encoded within non-coding RNA
A hallmark of all living organisms is the presence of genetic material within each cell; this material is invariantly composed of a specific class of biological molecules known as the nucleic acids. While the more familiar variety
Protection against production of cancer-causing agents in cooked meats by apple peel extracts
There is increasing evidence that the presence of cancer causing compounds in the diet are responsible for variations in cancer rates among different populations worldwide. Cancer causing agents are known to be generated during high temperature cooking
Effectiveness of an Internet intervention to decrease young adults’ risk for skin cancer
Every year, almost five million Americans are diagnosed with skin cancer. Though many think of cancer as being an issue for older people, melanoma is the second most diagnosed cancer in adults aged 20-39. This is in
