Tag Archives: cancer
A new three-headed, long-tailed molecular beast eats cancer
We made and tested a series of new compounds containing three chemical rings and hooked them to long carbon tails. These new molecules killed a broad range of pediatric and adult cancer cells including neuroblastoma, osteosarcoma, malignant
Do all children have equal access to Phase I cancer trials?
Approximately 60% of pediatric cancer patients participate in clinical trials compared to only 5% of adult cancer patients. These pediatric clinical trials have been instrumental in improving the 5-year survival rate of childhood and adolescent cancer patients
Identification of a new T cell regulator
T-cell receptor (TCR) signaling is mediated by the activation of protein-tyrosine kinases such as p56lck and ZAP-70. In mature T-cells, CD4 and CD8 molecules bind to p56lck which then phosphorylates the intracellular immune-receptor tyrosine-based activation motifs (ITAM)
Atomic structures of telomerase shed light into the mechanism of telomere replication
Telomeres comprise the six nucleotide repeats at the end of eukaryotic chromosomes and they are essential for the faithful replication and protection of our genome. Significant telomere attrition forces the cells to enter a dormant state to
Germ cell testicular cancer incidence
Testicular cancer is not your normal malignancy. A few cancers occur in children, while most occur in older people. However, hardly any occur specifically in young adults. Testicular cancer is one. Incidence rises rapidly in the teen
Annual Summit on Cell Signaling and Cancer Therapy. Chicago, USA. September 27-28, 2017
Annual Summit on Cell Signaling and Cancer Therapy is bustling to be held at Chicago, USA during September 27-28, 2017 hosted by Conferences Series. Through the theme “To Frame An Admiring Portal For Pioneering Cancer Therapy and
DNA methylation markers in colorectal cancer state-of-the-art
Colorectal is the fourth leading cause of cancer-related death worldwide. There were over 1.3 million new colorectal cancer cases worldwide, of which approximately 50% died as a result of the disease in 2012. Like all cancers, CRC
Drugs from the sea: complex structures to fight a complex problem of resistance in cancer
It is well known that incidence of cancer cases figures among the leading causes of morbidity and mortality. Most of disseminated cancers share the common feature of not responding to anticancer drugs. This phenomenon is known as
Mechanism of the tumor suppressive properties of glycodelin
Malignant growth in cancer is characterized by loss of cell differentiation, uncontrolled proliferation and resistance to apoptosis. In some cases it is possible to revert malignant cells back to normal. However, this process is not very well
Acute stroke in 3 brain territories suggests cancer
Over the past several decades cancer has increased to rival heart disease as the leading cause of death in the United States. Non-infectious endocarditis and cancer-associated hypercoagulation (C-AH) have both been suggested as a source of stroke
Teasing apart the roles that oncogenic miRNAs play in breast cancer
Oncogenic miRNA and breast cancer Since the early 2000’s, the field of RNA has been contributing to major discoveries in cancer research. McroRNAs are small RNA molecules (miRNA), inhibit the messenger RNAs that produce our proteins. Normally,
Could low albumin be a marker of an undiagnosed cancer?
Cancer is an increasingly common problem that affects one-in-two British people over the course of their lifetime. Survival rates are getting better with increased awareness, better tests and more effective treatments, but the UK still lags behind
Patterns of mutation in cancer genes
In most cancers, the majority of the changes to the DNA (termed mutations), acquired during the disease process are inconsequential in terms of driving the cancer, however a few of the changes in a small set of
Chronic lymphocytic leukemia (CLL) diagnostics better to do in cultivated than native cells
Cancer is an age associated disease. In Western countries with people having longer life expectancies than e.g. 100 years ago, this means at present that 1-2% of those individuals are confronted with the diagnosis of leukemia during
MicroRNAs identify high-risk colon cancer patients
Choosing the optimal anticancer treatment for each patient requires proper disease staging. Staging is usually assessed according to the TNM system: tumour size (T), number of nearby lymph nodes affected (N), and metastasis, or spread to other
Radiation-induced morphea: an under-recognized complication of breast radiation
Worldwide, breast cancer was the most common new diagnosis and common cause of death in women in 2012. As screening for breast cancer has improved patients are often identified in the early stage of disease and are
„Kill-ators” – fighting cancer with a claw
According to the WHO Cancer Report, cancer is the second most frequent cause of death in developed countries. In 2012 approximately 14 Mio people were diagnosed worldwide and more than 8 Mio people died from cancer. Despite
Hitting the sweet spot: Sialic acid sugars for the treatment of immune diseases and other disorders?
In addition to DNA, proteins and lipids, sugar molecules are essential building blocks for every living cell. There are many different types of sugar molecules in a cell which are linked to one another forming chain or
Is chromatin remodeling required to modulate embryonic development?
Chromatin remodeling is active critical process during embryonic development and in cellular malignancies such as cancer. Chromatin is the highly condensed form by which the genomic material (DNA) is packaged in the cell nucleus. The fundamental subunit
Microfluidic tumor models help pre-clinical screening of T cell cancer immunotherapies
Cancer immunotherapy draws upon the patient’s own immune system to recognize and fight the disease. One form of cancer immunotherapy is known as adoptive T cell therapy (ACT) consisting of isolation, genetic manipulation and reinfusion into the
