Tag Archives: enzyme
All You Need to Know About Protein Kinases
A fascinating field of biological study is that of genetics. Almost every ailment that a human can suffer from has some basis within their genes. As understanding grows within this ever-growing field of study, scientists are continuing
Discovery and mutation of a novel enzyme for the removal of environmental pollutants
Environmental pollution is one of the biggest challenges in the world today, as society faces the consequences of intense industrial development. The widespread use of pesticides in agriculture leads to high quality products, while minimizing losses in
Ultrasensitive enzyme immunoassay by immune complex transfer method
Many technologies have been developed to improve the sensitivity of immunoassays, such as high affinity antibodies, specific conjugations using the hinge region of Fab’ fragments, highly active enzymes, and digital counting systems. We described a methodology called
Camphor biodegradation by Pseudomonas putida plays a key role in carbon cycling in the biosphere
The key role of microorganisms in promoting carbon cycling in the biosphere is well illustrated by the biodegradation of the natural plant terpenoid camphor by Pseudomonas putida ATCC 17453. Research has established that several different monooxygenases (cytochromeP450
The immunomodulatory enzyme IDO: Expression in the uterus of mares?
IDO modulates immune responses. The enzyme indoleamine 2,3-dioxygenase 1 (IDO) degrades tryptophan. This amino acid is required for immune defences against pathogens, but also stimulates pathogen growth. Its degradation inhibits effector lymphocytes and retards pathogen proliferation. Thus,
Novel biosensors for the rapid detection of toxicants in foods
The specific objective of this monograph is mainly to exploit progress in nanosciences to deploy nanotechnology in affordable, mass-produced sensors, and to integrate these into components and systems (including portable ones) for mass market applications in environmental
Creating artificial enzymes from small building blocks
Artificial enzymes were first described several decades ago and have become an ambition for bionanomaterial sciences. Artificial enzymes are small fabricated molecules that possess an active centre, which binds to a substrate and catalyses a chemical reaction.
The lysosomal enzyme cathepsin D as novel therapeutic target for non-alcoholic steatohepatitis
The decrease in physical activity combined with increased caloric intake has led us to a global obesity epidemic. Obese patients can develop metabolic syndrome (MetS), which is a term used to assess the risk of a patient
Nano-impacts: A new perspective on enzymes
Enzymes are an integral part of all living organisms and play a central role in a wide range of biological processes. The latter, among many, include most biological metabolism as for instance the digestion of food in
Enzyme-based computing systems: The half-adder and half-subtractor
Have we ever stopped to think what would happen if the silicon based computers that we have come to rely on reach the peak of their development? Many scientists who work in the field of unconventional computing
Truncated INH-NAD adduct, an active intermediate in the action of Isoniazid (INH) against InhA enzyme in tuberculosis
Tuberculosis (TB) remains as an important infectious disease, caused by Mycobacterium tuberculosis (MTB) which is responsible for around 1.5 million deaths and 9.6 million new cases annually. Isoniazid (INH), a bactericidal compound used as a first-line drug
Understanding how enzyme injection for Dupuytren’s disease works
The fascia of the hand is a thin layer of connective tissue that wraps around the muscles, tendons, and neurovascular constitutions in the palm of the hand, providing structural support and integrity. The palmar and digital fascia
Ribose hydroxyl group summary
We usually think of enzymes – the molecules that drive all the reactions in our cells – as being proteins, but many scientists believe that the earliest enzymes may have been made of RNA. RNA, which is
How do chaperones save protein folding?
Protein folding both in vitro and in vivo goes via formation of intermediate states. These “molten globule”-like states fluctuate, expose their hydrophobic sites and therefore easily aggregate. This retards or even inhibits formation of protein native structures,
A novel reovirus mutant: toward the next generation of viruses for cancer treatment?
In the last decade or so, it has been realized that viruses are not only foes to fight, but possible therapeutics against diseases such as cancer. Most of these so-called oncolytic viruses are engineered to acquire desirable
Pre-treatment is important in the utilisation of food waste for the production of high value products
Proper disposal of food industry waste is a problem that developed as well as developing economies face alike. Conversion of food waste is a pioneering idea which can lead to huge financial gains while ensuring a healthy
Janus subcompartmentalized microreactors
When we are sick and have to take medicine, the first thing we do, is reading the package leaflet. We want to know the potential side effects of the drug. Sometimes the side effect of one drug
A versatile oxygenase family
Enzymes catalyze important biological processes throughout all kingdoms of life. One large and highly versatile enzyme family possesses a three-dimensional structure containing a double-stranded beta-helix (or jellyroll) protein fold that typically has a 2-histidine-1-carboxylate amino acid motif
